Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079772717> ?p ?o ?g. }
- W2079772717 endingPage "196" @default.
- W2079772717 startingPage "193" @default.
- W2079772717 abstract "Islets of patients with type 2 diabetes display the typical features of an inflammatory process characterized by the presence of cytokines, chemokines, immune cell infiltration, impaired function and tissue destruction with fibrotic areas. Functional studies have shown that targeting inflammation may improve insulin secretion and sensitivity. In particular clinical proof of concept studies using modulators of the interleukin‐1β ( IL ‐1β)—nuclear factor‐κB ( NF‐κB ) pathway demonstrated the role of the innate immune system in type 2 diabetes. This programme has now entered the phase 3 of clinical development. Other targets such as tumour necrosis factor α ( TNFα ) may be equally important but have been neglected based on poorly designed studies. In this article we discuss the mechanisms of islet inflammation in type 2 diabetes and review the opportunity of clinical translation." @default.
- W2079772717 created "2016-06-24" @default.
- W2079772717 creator A5017674179 @default.
- W2079772717 date "2013-09-01" @default.
- W2079772717 modified "2023-09-25" @default.
- W2079772717 title "Targeting inflammation in the treatment of type 2 diabetes" @default.
- W2079772717 cites W1515994079 @default.
- W2079772717 cites W1967724716 @default.
- W2079772717 cites W1972483153 @default.
- W2079772717 cites W1990902267 @default.
- W2079772717 cites W1997349446 @default.
- W2079772717 cites W1998221258 @default.
- W2079772717 cites W1999540978 @default.
- W2079772717 cites W2009800174 @default.
- W2079772717 cites W2010447832 @default.
- W2079772717 cites W2011200290 @default.
- W2079772717 cites W2013531988 @default.
- W2079772717 cites W2018135697 @default.
- W2079772717 cites W2018607502 @default.
- W2079772717 cites W2024378513 @default.
- W2079772717 cites W2033958293 @default.
- W2079772717 cites W2034946303 @default.
- W2079772717 cites W2039664878 @default.
- W2079772717 cites W2040245081 @default.
- W2079772717 cites W2045030683 @default.
- W2079772717 cites W2051303794 @default.
- W2079772717 cites W2058312167 @default.
- W2079772717 cites W2064938665 @default.
- W2079772717 cites W2066191605 @default.
- W2079772717 cites W2071073097 @default.
- W2079772717 cites W2072781226 @default.
- W2079772717 cites W2098000380 @default.
- W2079772717 cites W2102177965 @default.
- W2079772717 cites W2108192985 @default.
- W2079772717 cites W2110500106 @default.
- W2079772717 cites W2113145530 @default.
- W2079772717 cites W2115896586 @default.
- W2079772717 cites W2118968774 @default.
- W2079772717 cites W2125058279 @default.
- W2079772717 cites W2127647469 @default.
- W2079772717 cites W2129316761 @default.
- W2079772717 cites W2134285290 @default.
- W2079772717 cites W2137334382 @default.
- W2079772717 cites W2150702412 @default.
- W2079772717 cites W2151672809 @default.
- W2079772717 cites W2151729372 @default.
- W2079772717 cites W2163109807 @default.
- W2079772717 cites W2169273342 @default.
- W2079772717 cites W2411826498 @default.
- W2079772717 cites W4237379391 @default.
- W2079772717 cites W4242514389 @default.
- W2079772717 doi "https://doi.org/10.1111/dom.12172" @default.
- W2079772717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24003937" @default.
- W2079772717 hasPublicationYear "2013" @default.
- W2079772717 type Work @default.
- W2079772717 sameAs 2079772717 @default.
- W2079772717 citedByCount "60" @default.
- W2079772717 countsByYear W20797727172014 @default.
- W2079772717 countsByYear W20797727172015 @default.
- W2079772717 countsByYear W20797727172016 @default.
- W2079772717 countsByYear W20797727172017 @default.
- W2079772717 countsByYear W20797727172018 @default.
- W2079772717 countsByYear W20797727172019 @default.
- W2079772717 countsByYear W20797727172020 @default.
- W2079772717 countsByYear W20797727172021 @default.
- W2079772717 countsByYear W20797727172022 @default.
- W2079772717 countsByYear W20797727172023 @default.
- W2079772717 crossrefType "journal-article" @default.
- W2079772717 hasAuthorship W2079772717A5017674179 @default.
- W2079772717 hasBestOaLocation W20797727171 @default.
- W2079772717 hasConcept C126322002 @default.
- W2079772717 hasConcept C13373296 @default.
- W2079772717 hasConcept C134018914 @default.
- W2079772717 hasConcept C136449434 @default.
- W2079772717 hasConcept C165220095 @default.
- W2079772717 hasConcept C17991360 @default.
- W2079772717 hasConcept C203014093 @default.
- W2079772717 hasConcept C2776914184 @default.
- W2079772717 hasConcept C2777180221 @default.
- W2079772717 hasConcept C2781232474 @default.
- W2079772717 hasConcept C49039625 @default.
- W2079772717 hasConcept C555293320 @default.
- W2079772717 hasConcept C60644358 @default.
- W2079772717 hasConcept C71924100 @default.
- W2079772717 hasConcept C86803240 @default.
- W2079772717 hasConcept C8891405 @default.
- W2079772717 hasConceptScore W2079772717C126322002 @default.
- W2079772717 hasConceptScore W2079772717C13373296 @default.
- W2079772717 hasConceptScore W2079772717C134018914 @default.
- W2079772717 hasConceptScore W2079772717C136449434 @default.
- W2079772717 hasConceptScore W2079772717C165220095 @default.
- W2079772717 hasConceptScore W2079772717C17991360 @default.
- W2079772717 hasConceptScore W2079772717C203014093 @default.
- W2079772717 hasConceptScore W2079772717C2776914184 @default.
- W2079772717 hasConceptScore W2079772717C2777180221 @default.
- W2079772717 hasConceptScore W2079772717C2781232474 @default.
- W2079772717 hasConceptScore W2079772717C49039625 @default.
- W2079772717 hasConceptScore W2079772717C555293320 @default.