FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079774097> ?p ?o ?g. }

• W2079774097 endingPage "120" @default.
• W2079774097 startingPage "110" @default.
• W2079774097 abstract "Osteosarcoma is the most common primary malignant tumor of bone and accounts for half of all primary skeletal malignancies in children and teenagers. The prognosis for patients who fail or progress on first-line chemotherapy protocols is poor, therefore, additional adjuvant therapeutic strategies are needed. A recent feasibility study has demonstrated that the nitrogen-containing bisphosphonate zoledronic acid (ZOL) can be combined safely with conventional chemotherapy. However, the pharmacodynamics of bisphosphonate therapy is not well characterized. Osteosarcoma is a highly angiogenic tumor. Recent reports of the anti-angiogenic effects of bisphosphonates prompted us to determine whether nitrogen-containing bisphosphonate (ZOL and alendronate) treatment attenuates osteosarcoma growth by inhibition of osteoclast activity, tumor-mediated angiogenesis, or direct inhibitory effects on osteosarcoma. Here, we demonstrate that bisphosphonates directly inhibit VEGFR2 expression in endothelial cells, as well as endothelial cell proliferation and migration. Additionally, bisphosphonates also decrease VEGF-A expression in osteosarcoma (K7M3) cells, resulting in reduced stimulation of endothelial cell migration in co-culture assays. ZOL also decreases VEGFR1 expression in aggressive osteosarcoma cell lines (K7M3, 143B) and induces apoptosis of these cells, but has negligible effects on less aggressive osteosarcoma cell lines (K12 and TE85). In vivo ZOL treatment results in significant reduction in osteosarcoma-initiated angiogenesis and tumor growth in a murine model of osteosarcoma. In conclusion, bisphosphonates have diverse growth inhibitory effects on osteosarcoma through: (1) activation of apoptosis and inhibition of cell proliferation, (2) inhibition of VEGF-A and VEGFR1 expression by tumor cells, (3) inhibition of tumor-induced angiogenesis, and (4) direct inhibitory actions on endothelial cells." @default.
• W2079774097 created "2016-06-24" @default.
• W2079774097 creator A5003143622 @default.
• W2079774097 creator A5006759821 @default.
• W2079774097 creator A5011503594 @default.
• W2079774097 creator A5015343041 @default.
• W2079774097 creator A5022763793 @default.
• W2079774097 creator A5022984651 @default.
• W2079774097 creator A5045358290 @default.
• W2079774097 creator A5073289445 @default.
• W2079774097 creator A5079357462 @default.
• W2079774097 date "2014-06-01" @default.
• W2079774097 modified "2023-10-06" @default.
• W2079774097 title "Pleiotropic effects of bisphosphonates on osteosarcoma" @default.
• W2079774097 cites W1588736822 @default.
• W2079774097 cites W1595998158 @default.
• W2079774097 cites W1625279067 @default.
• W2079774097 cites W1821095830 @default.
• W2079774097 cites W1918337600 @default.
• W2079774097 cites W1966293734 @default.
• W2079774097 cites W19745091 @default.
• W2079774097 cites W1977898942 @default.
• W2079774097 cites W1996799211 @default.
• W2079774097 cites W1998077412 @default.
• W2079774097 cites W2000292756 @default.
• W2079774097 cites W2005334224 @default.
• W2079774097 cites W2011863782 @default.
• W2079774097 cites W2013320864 @default.
• W2079774097 cites W2014163604 @default.
• W2079774097 cites W2017624163 @default.
• W2079774097 cites W2023292535 @default.
• W2079774097 cites W2026312732 @default.
• W2079774097 cites W2026996188 @default.
• W2079774097 cites W2030471654 @default.
• W2079774097 cites W2037475800 @default.
• W2079774097 cites W2057251076 @default.
• W2079774097 cites W2063846327 @default.
• W2079774097 cites W2074130273 @default.
• W2079774097 cites W2076424556 @default.
• W2079774097 cites W2077174583 @default.
• W2079774097 cites W2088796820 @default.
• W2079774097 cites W2093164779 @default.
• W2079774097 cites W2100654207 @default.
• W2079774097 cites W2112264523 @default.
• W2079774097 cites W2129988610 @default.
• W2079774097 cites W2133072189 @default.
• W2079774097 cites W2144427391 @default.
• W2079774097 cites W2144860907 @default.
• W2079774097 cites W2155393958 @default.
• W2079774097 cites W2156683343 @default.
• W2079774097 cites W2159436449 @default.
• W2079774097 cites W2164327861 @default.
• W2079774097 cites W2170309090 @default.
• W2079774097 cites W4229737095 @default.
• W2079774097 doi "https://doi.org/10.1016/j.bone.2014.03.005" @default.
• W2079774097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24636958" @default.
• W2079774097 hasPublicationYear "2014" @default.
• W2079774097 type Work @default.
• W2079774097 sameAs 2079774097 @default.
• W2079774097 citedByCount "30" @default.
• W2079774097 countsByYear W20797740972014 @default.
• W2079774097 countsByYear W20797740972015 @default.
• W2079774097 countsByYear W20797740972016 @default.
• W2079774097 countsByYear W20797740972017 @default.
• W2079774097 countsByYear W20797740972018 @default.
• W2079774097 countsByYear W20797740972019 @default.
• W2079774097 countsByYear W20797740972020 @default.
• W2079774097 countsByYear W20797740972021 @default.
• W2079774097 countsByYear W20797740972022 @default.
• W2079774097 crossrefType "journal-article" @default.
• W2079774097 hasAuthorship W2079774097A5003143622 @default.
• W2079774097 hasAuthorship W2079774097A5006759821 @default.
• W2079774097 hasAuthorship W2079774097A5011503594 @default.
• W2079774097 hasAuthorship W2079774097A5015343041 @default.
• W2079774097 hasAuthorship W2079774097A5022763793 @default.
• W2079774097 hasAuthorship W2079774097A5022984651 @default.
• W2079774097 hasAuthorship W2079774097A5045358290 @default.
• W2079774097 hasAuthorship W2079774097A5073289445 @default.
• W2079774097 hasAuthorship W2079774097A5079357462 @default.
• W2079774097 hasConcept C126322002 @default.
• W2079774097 hasConcept C190283241 @default.
• W2079774097 hasConcept C2776326535 @default.
• W2079774097 hasConcept C2776541429 @default.
• W2079774097 hasConcept C2777251235 @default.
• W2079774097 hasConcept C2777760704 @default.
• W2079774097 hasConcept C2780394083 @default.
• W2079774097 hasConcept C502942594 @default.
• W2079774097 hasConcept C54355233 @default.
• W2079774097 hasConcept C55493867 @default.
• W2079774097 hasConcept C62112901 @default.
• W2079774097 hasConcept C71924100 @default.
• W2079774097 hasConcept C86803240 @default.
• W2079774097 hasConceptScore W2079774097C126322002 @default.
• W2079774097 hasConceptScore W2079774097C190283241 @default.
• W2079774097 hasConceptScore W2079774097C2776326535 @default.
• W2079774097 hasConceptScore W2079774097C2776541429 @default.
• W2079774097 hasConceptScore W2079774097C2777251235 @default.
• W2079774097 hasConceptScore W2079774097C2777760704 @default.

• next