FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079774530> ?p ?o ?g. }

• W2079774530 abstract "Coenzyme Q10 (CoQ10, ubiquinone) is a highly mobile electron carrier in the mitochondrial respiratory chain that also acts as an antioxidant. We evaluated the neuroprotective efficacy of CoQ10 against fatality in an experimental model of endotoxemia that mimics systemic inflammatory response syndrome using a novel water-soluble formulation of this quinone derivative. Experiments were conducted in adult male Sprague-Dawley rats that were maintained under propofol anesthesia. Intravenous administration of Escherichia coli lipopolysaccharide (LPS; 30 mg/kg) induced progressive hypotension, with death ensuing within 4 h. The sequence of cardiovascular events during this LPS-induced endotoxemia can be divided into a reduction (Phase I), followed by an augmentation (Phase II; pro-life phase) and a secondary decrease (Phase III; pro-death phase) in the power density of the vasomotor components (0-0.8 Hz) of systemic arterial pressure signals. Pretreatment by microinjection bilaterally of CoQ10 (1 or 2 microg) into the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic vasomotor tone, significantly diminished mortality, prolonged survival time, and reduced the slope or magnitude of the LPS-induced hypotension. CoQ10 pretreatment also significantly prolonged the duration of and augmented the total power density of the vasomotor components of systemic arterial pressure signals in Phase II endotoxemia. The increase in superoxide anion production induced by LPS at the RVLM during Phases II and III endotoxemia was also significantly blunted. We conclude that CoQ10 provides neuroprotection against fatality during experimental endotoxemia by reducing superoxide anion production at the RVLM, whose neuronal activity is intimately related to the life-and-death process." @default.
• W2079774530 created "2016-06-24" @default.
• W2079774530 creator A5012483729 @default.
• W2079774530 creator A5067438833 @default.
• W2079774530 creator A5079119110 @default.
• W2079774530 creator A5080035611 @default.
• W2079774530 creator A5081985168 @default.
• W2079774530 creator A5083315383 @default.
• W2079774530 creator A5085078759 @default.
• W2079774530 date "2003-05-01" @default.
• W2079774530 modified "2023-09-24" @default.
• W2079774530 title "Neuroprotective Effects of Coenzyme Q10 at Rostral Ventrolateral Medulla Against Fatality During Experimental Endotoxemia in the Rat" @default.
• W2079774530 cites W1573392996 @default.
• W2079774530 cites W166801957 @default.
• W2079774530 cites W1964121273 @default.
• W2079774530 cites W1971897459 @default.
• W2079774530 cites W1983372965 @default.
• W2079774530 cites W1985264236 @default.
• W2079774530 cites W1990020965 @default.
• W2079774530 cites W1997047318 @default.
• W2079774530 cites W1999377197 @default.
• W2079774530 cites W2001565942 @default.
• W2079774530 cites W2046148623 @default.
• W2079774530 cites W2049477910 @default.
• W2079774530 cites W2052036612 @default.
• W2079774530 cites W2064347448 @default.
• W2079774530 cites W2085366528 @default.
• W2079774530 cites W2085573708 @default.
• W2079774530 cites W2100454943 @default.
• W2079774530 cites W2114561146 @default.
• W2079774530 cites W2137672734 @default.
• W2079774530 cites W2145648029 @default.
• W2079774530 cites W2161062763 @default.
• W2079774530 cites W2212107724 @default.
• W2079774530 cites W2431738904 @default.
• W2079774530 cites W261049278 @default.
• W2079774530 cites W4230634566 @default.
• W2079774530 cites W4238552834 @default.
• W2079774530 cites W4242828560 @default.
• W2079774530 doi "https://doi.org/10.1097/01.shk.0000048900.46342.37" @default.
• W2079774530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12744485" @default.
• W2079774530 hasPublicationYear "2003" @default.
• W2079774530 type Work @default.
• W2079774530 sameAs 2079774530 @default.
• W2079774530 citedByCount "33" @default.
• W2079774530 countsByYear W20797745302012 @default.
• W2079774530 countsByYear W20797745302015 @default.
• W2079774530 countsByYear W20797745302017 @default.
• W2079774530 countsByYear W20797745302018 @default.
• W2079774530 countsByYear W20797745302019 @default.
• W2079774530 crossrefType "journal-article" @default.
• W2079774530 hasAuthorship W2079774530A5012483729 @default.
• W2079774530 hasAuthorship W2079774530A5067438833 @default.
• W2079774530 hasAuthorship W2079774530A5079119110 @default.
• W2079774530 hasAuthorship W2079774530A5080035611 @default.
• W2079774530 hasAuthorship W2079774530A5081985168 @default.
• W2079774530 hasAuthorship W2079774530A5083315383 @default.
• W2079774530 hasAuthorship W2079774530A5085078759 @default.
• W2079774530 hasBestOaLocation W20797745301 @default.
• W2079774530 hasConcept C126322002 @default.
• W2079774530 hasConcept C134018914 @default.
• W2079774530 hasConcept C181199279 @default.
• W2079774530 hasConcept C185592680 @default.
• W2079774530 hasConcept C25498285 @default.
• W2079774530 hasConcept C2776214587 @default.
• W2079774530 hasConcept C2778110749 @default.
• W2079774530 hasConcept C2780795997 @default.
• W2079774530 hasConcept C33114225 @default.
• W2079774530 hasConcept C42219234 @default.
• W2079774530 hasConcept C529278444 @default.
• W2079774530 hasConcept C55493867 @default.
• W2079774530 hasConcept C62525196 @default.
• W2079774530 hasConcept C71924100 @default.
• W2079774530 hasConcept C98274493 @default.
• W2079774530 hasConceptScore W2079774530C126322002 @default.
• W2079774530 hasConceptScore W2079774530C134018914 @default.
• W2079774530 hasConceptScore W2079774530C181199279 @default.
• W2079774530 hasConceptScore W2079774530C185592680 @default.
• W2079774530 hasConceptScore W2079774530C25498285 @default.
• W2079774530 hasConceptScore W2079774530C2776214587 @default.
• W2079774530 hasConceptScore W2079774530C2778110749 @default.
• W2079774530 hasConceptScore W2079774530C2780795997 @default.
• W2079774530 hasConceptScore W2079774530C33114225 @default.
• W2079774530 hasConceptScore W2079774530C42219234 @default.
• W2079774530 hasConceptScore W2079774530C529278444 @default.
• W2079774530 hasConceptScore W2079774530C55493867 @default.
• W2079774530 hasConceptScore W2079774530C62525196 @default.
• W2079774530 hasConceptScore W2079774530C71924100 @default.
• W2079774530 hasConceptScore W2079774530C98274493 @default.
• W2079774530 hasLocation W20797745301 @default.
• W2079774530 hasLocation W20797745302 @default.
• W2079774530 hasOpenAccess W2079774530 @default.
• W2079774530 hasPrimaryLocation W20797745301 @default.
• W2079774530 hasRelatedWork W1998351332 @default.
• W2079774530 hasRelatedWork W2011380907 @default.
• W2079774530 hasRelatedWork W2035825238 @default.
• W2079774530 hasRelatedWork W2047079958 @default.
• W2079774530 hasRelatedWork W2079774530 @default.
• W2079774530 hasRelatedWork W2899084033 @default.
• W2079774530 hasRelatedWork W2976564201 @default.

• next