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• W2079777655 endingPage "1258" @default.
• W2079777655 startingPage "1253" @default.
• W2079777655 abstract "The nucleotide sequence of the plasmid pRA1 gene encoding the TetA(D) tetracycline/H+ antiporter was determined. The deduced amino acid sequence was compared with those of other antimicrobial and antiseptic transporters. The deduced product of tetA(D) is a 41.1-kDa protein consisting of 394 amino acids comprising 12 membrane-spanning domains. Three classes of amino acid motifs found in TetA(D) are highly conserved in other transporters, implying that they participate in structures necessary for substrate recognition, binding, or translocation. A common mechanism of transport is suggested, with subtle sequence variations accounting for varied substrate specificities, modes of transport, and directions of transport." @default.
• W2079777655 created "2016-06-24" @default.
• W2079777655 creator A5059635755 @default.
• W2079777655 creator A5064310164 @default.
• W2079777655 date "1993-06-01" @default.
• W2079777655 modified "2023-09-23" @default.
• W2079777655 title "Nucleotide and deduced protein sequences of the class D tetracycline resistance determinant: relationship to other antimicrobial transport proteins" @default.
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• W2079777655 doi "https://doi.org/10.1128/aac.37.6.1253" @default.
• W2079777655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187949" @default.
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• W2079777655 hasPublicationYear "1993" @default.
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