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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079778210> ?p ?o ?g. }

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• W2079778210 abstract "Nicking of diphtheria toxin (DT), i.e. proteolytic cleavage at an arginine-rich region within the first disulphide loop, is a prerequisite to the intoxication process. We show that protease(s) required in this process was synthesized and secreted by the sensitive cells and that antibodies against plasminogen activator urokinase (uPA) decreased the in vitro cytotoxicity of DT on Vero cells. Our results demonstrate that uPA secreted by Vero cells cultured in vitro is one of the cellular proteases involved in the cleavage and activation of diphtheria toxin." @default.
• W2079778210 created "2016-06-24" @default.
• W2079778210 creator A5073205982 @default.
• W2079778210 date "1996-01-01" @default.
• W2079778210 modified "2023-09-25" @default.
• W2079778210 title "Contribution of plasminogen activator urokinase to in vitro cytotoxicity of diphtheria toxin" @default.
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• W2079778210 doi "https://doi.org/10.1016/s0923-2508(97)85117-0" @default.
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