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- W2079778594 abstract "Bevacizumab in combination with interferon alfa is now approved for treatment-naïve advanced renal cell carcinoma (RCC) in both the US and Europe. Its objective response rates of 30% and progression-free survival rates of 9-10 months are comparable to the other approved first-line multityrosine kinase inhibitors, sunitinib and pazopanib. Its advantages include a different toxicity profile and assurance of administration compliance given its intravenous formulation. Enthusiasm for its use is blunted by the increased costs, the potential infusion-related reactions, the associated interferon-related toxicities, and the inconvenience of its nonoral formulation. Further study is warranted to assess its efficacy both as a single agent and in combination with the targeted agents and other immunotherapies. With multiple agents now available for the treatment of advanced RCC, identification of patient and tumor-specific biomarkers to inform our choice of first-line therapy and the proper sequence of subsequent therapies is imperative." @default.
- W2079778594 created "2016-06-24" @default.
- W2079778594 creator A5055738663 @default.
- W2079778594 creator A5087836779 @default.
- W2079778594 date "2010-09-01" @default.
- W2079778594 modified "2023-10-10" @default.
- W2079778594 title "The bevacizumab experience in advanced renal cell carcinoma" @default.
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- W2079778594 doi "https://doi.org/10.2147/ott.s8157" @default.
- W2079778594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2962304" @default.
- W2079778594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21049084" @default.
- W2079778594 hasPublicationYear "2010" @default.
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