FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079778822> ?p ?o ?g. }

• W2079778822 endingPage "281" @default.
• W2079778822 startingPage "276" @default.
• W2079778822 abstract "Objectives To investigate the associations between the apolipoprotein E ( APOE ) ε 4 allele, carbon dioxide ( CO 2 ) vasoreactivity, and cognitive performance and to explore the effect of CO 2 vasoreactivity and hypertension on the associations between APOE and cognition. Design Observational. Setting Community. Participants Older adults (N = 625) enrolled in the Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly of Boston Study. Measurements Change in cerebral blood flow velocity in response to CO 2 challenge ( CO 2 ), measured using transcranial Doppler ultrasonography, Trail‐Making Test Part B – A ( TMT ), Hopkins Verbal Learning Test delayed recall ( HVLT ). Results APOE ‐ ε 4 was associated with lower CO 2 vasoreactivity ( P = .009) and poorer performance on the TMT ( P < .001) and HVLT ( P < .001). Having hypertension and APOE ‐ ε 4 was associated with worse cognitive and CO 2 vasoreactivity measures than having neither or either alone ( P < .001 for TMT and HVLT , P = .01 for CO 2 vasoreactivity). The association between APOE ‐ ε 4 and cognition was only significant if it was present concurrent with low CO 2 vasoreactivity, defined as below the median of the sample ( APOE by CO 2 vasoreactivity interaction: P = .04 for TMT , P = .04 for HVLT ). In hypertension, the association between APOE ‐ ε 4 and executive function was also only significant in participants with lower CO 2 vasoreactivity ( P = .005 for APOE by CO 2 vasoreactivity). Conclusion Individuals at risk of Alzheimer's disease ( AD ) because they have APOE ‐ ε 4 may have lower CO 2 vasoreactivity, which in turn may be contributing to the observed lower cognitive performance associated with this allele. The cognitive effect of APOE ‐ ε 4 is magnified in hypertension and low CO 2 vasoreactivity. This study offers evidence that APOE ‐ ε 4 may be associated with microvascular brain injury even in the absence of clinical AD ." @default.
• W2079778822 created "2016-06-24" @default.
• W2079778822 creator A5026936534 @default.
• W2079778822 creator A5035175263 @default.
• W2079778822 creator A5035589814 @default.
• W2079778822 date "2015-02-01" @default.
• W2079778822 modified "2023-10-17" @default.
• W2079778822 title "Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension" @default.
• W2079778822 cites W1560319839 @default.
• W2079778822 cites W1926001191 @default.
• W2079778822 cites W1966447594 @default.
• W2079778822 cites W1973065853 @default.
• W2079778822 cites W1973375565 @default.
• W2079778822 cites W1973935404 @default.
• W2079778822 cites W1981541008 @default.
• W2079778822 cites W1994259160 @default.
• W2079778822 cites W1998494497 @default.
• W2079778822 cites W1999311530 @default.
• W2079778822 cites W2000984969 @default.
• W2079778822 cites W2009009921 @default.
• W2079778822 cites W2009339691 @default.
• W2079778822 cites W2026903562 @default.
• W2079778822 cites W2031762899 @default.
• W2079778822 cites W2048842952 @default.
• W2079778822 cites W2049733019 @default.
• W2079778822 cites W2063225300 @default.
• W2079778822 cites W2087653213 @default.
• W2079778822 cites W2088526201 @default.
• W2079778822 cites W2091924214 @default.
• W2079778822 cites W2097112082 @default.
• W2079778822 cites W2113857565 @default.
• W2079778822 cites W2118997136 @default.
• W2079778822 cites W2130159618 @default.
• W2079778822 cites W2134115481 @default.
• W2079778822 cites W2151380782 @default.
• W2079778822 cites W2153425956 @default.
• W2079778822 cites W2162417593 @default.
• W2079778822 cites W292742767 @default.
• W2079778822 doi "https://doi.org/10.1111/jgs.13235" @default.
• W2079778822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4375955" @default.
• W2079778822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25688603" @default.
• W2079778822 hasPublicationYear "2015" @default.
• W2079778822 type Work @default.
• W2079778822 sameAs 2079778822 @default.
• W2079778822 citedByCount "30" @default.
• W2079778822 countsByYear W20797788222015 @default.
• W2079778822 countsByYear W20797788222016 @default.
• W2079778822 countsByYear W20797788222017 @default.
• W2079778822 countsByYear W20797788222018 @default.
• W2079778822 countsByYear W20797788222019 @default.
• W2079778822 countsByYear W20797788222020 @default.
• W2079778822 countsByYear W20797788222021 @default.
• W2079778822 countsByYear W20797788222022 @default.
• W2079778822 crossrefType "journal-article" @default.
• W2079778822 hasAuthorship W2079778822A5026936534 @default.
• W2079778822 hasAuthorship W2079778822A5035175263 @default.
• W2079778822 hasAuthorship W2079778822A5035589814 @default.
• W2079778822 hasBestOaLocation W20797788222 @default.
• W2079778822 hasConcept C118552586 @default.
• W2079778822 hasConcept C126322002 @default.
• W2079778822 hasConcept C164705383 @default.
• W2079778822 hasConcept C169900460 @default.
• W2079778822 hasConcept C191616109 @default.
• W2079778822 hasConcept C2778355293 @default.
• W2079778822 hasConcept C2779134260 @default.
• W2079778822 hasConcept C2779483572 @default.
• W2079778822 hasConcept C2984863031 @default.
• W2079778822 hasConcept C2984915365 @default.
• W2079778822 hasConcept C548259974 @default.
• W2079778822 hasConcept C57089818 @default.
• W2079778822 hasConcept C71924100 @default.
• W2079778822 hasConceptScore W2079778822C118552586 @default.
• W2079778822 hasConceptScore W2079778822C126322002 @default.
• W2079778822 hasConceptScore W2079778822C164705383 @default.
• W2079778822 hasConceptScore W2079778822C169900460 @default.
• W2079778822 hasConceptScore W2079778822C191616109 @default.
• W2079778822 hasConceptScore W2079778822C2778355293 @default.
• W2079778822 hasConceptScore W2079778822C2779134260 @default.
• W2079778822 hasConceptScore W2079778822C2779483572 @default.
• W2079778822 hasConceptScore W2079778822C2984863031 @default.
• W2079778822 hasConceptScore W2079778822C2984915365 @default.
• W2079778822 hasConceptScore W2079778822C548259974 @default.
• W2079778822 hasConceptScore W2079778822C57089818 @default.
• W2079778822 hasConceptScore W2079778822C71924100 @default.
• W2079778822 hasFunder F4320332161 @default.
• W2079778822 hasFunder F4320337337 @default.
• W2079778822 hasIssue "2" @default.
• W2079778822 hasLocation W20797788221 @default.
• W2079778822 hasLocation W20797788222 @default.
• W2079778822 hasLocation W20797788223 @default.
• W2079778822 hasLocation W20797788224 @default.
• W2079778822 hasOpenAccess W2079778822 @default.
• W2079778822 hasPrimaryLocation W20797788221 @default.
• W2079778822 hasRelatedWork W1480959656 @default.
• W2079778822 hasRelatedWork W148236777 @default.
• W2079778822 hasRelatedWork W2111401088 @default.
• W2079778822 hasRelatedWork W2145580566 @default.
• W2079778822 hasRelatedWork W2147031368 @default.

• next