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• W2079780412 abstract "Glucocorticoids are the most effective anti-inflammatory drugs used in the treatment of inflammatory diseases. While phosphorylation of histone H3 at serine 10 (p-Ser10) is one of the histone modifications related to transcription of some inflammation-related genes, the effect of glucocorticoids on p-Ser10 is not established. Here, we investigated the ability of dexamethasone (Dex) to inhibit p-Ser10 expression in response to tumor necrosis factor (TNF-α) in the human lung adenocarcinoma cell line A549 and the SV-40-transformed human airway epithelial cell line BEAS-2B. By Western blot analysis in BEAS-2B cells, the expression of p-Ser10 was repressed by pretreatment with Dex, an effect not seen in A549 cells. Flow cytometric analysis at a single-cell level in A549 cells indicated that TNF-α treatment caused early induction of p-Ser10 at 15 min, which was inhibited significantly by pretreatment with 10−5 M Dex. By immunostaining, the p-Ser10 signal appeared as granules in TNF-α-treated cells at same sites of phosphorylated RNA polymerase II. In contrast, the signal was scattered in the nuclei of Dex-pretreated cells. These findings suggested that Dex limits airway inflammation by inhibiting p-Ser10 expression and redistributing p-Ser10 away from transcription sites." @default.
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• W2079780412 date "2005-11-01" @default.
• W2079780412 modified "2023-10-16" @default.
• W2079780412 title "Dexamethasone inhibits phosphorylation of histone H3 at serine 10" @default.
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• W2079780412 doi "https://doi.org/10.1016/j.bbrc.2005.08.231" @default.
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