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- W2079780959 abstract "Cancer kills over 500,000 people in the US every year. Aberrant function of key genomic regulators for cell growth, death, lifespan, and cell–cell interaction is a hallmark of the cancer cell. Such massive dysregulation has a major epigenetic component imposed onto the DNA by heritable alterations of chromatin structure, a phenomenon recently discovered to underlie all genome regulatory circuits in eukarya. Study of chromatin-based genome control pathways in cancer illuminates disease mechanisms amenable to targeted therapeutic intervention." @default.
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- W2079780959 date "2004-10-01" @default.
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- W2079780959 title "Chromatin targets: reading and writing the cancer cell epigenome" @default.
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- W2079780959 doi "https://doi.org/10.1016/j.ddmod.2004.08.002" @default.
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