FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079781775> ?p ?o ?g. }

• W2079781775 endingPage "555" @default.
• W2079781775 startingPage "545" @default.
• W2079781775 abstract "Low molecular weight protein tyrosine phosphatase (LMW-PTP) was cloned from human lens epithelial B3 cells (HLE B3) and the recombinant enzyme was purified to homogeneity. The pure enzyme reacted positively with anti-LMW-PTP antibody, displayed tyrosine-specific phosphatase activity and was extremely sensitive to H(2)O(2). The inactivated LMW-PTP could be regenerated by thioltransferase (TTase)/GSH system as demonstrated by both activity assay and by mass spectrometry (MS). The MS study also showed that an intramolecular disulfide bond was formed between C13 and C18 at the active site, and was reduced by the TTase/GSH system. The putative role of LMW-PTP in regulating platelet derived growth factor (PDGF)-stimulated cell signaling was demonstrated in wild type mouse lens epithelial cells (LEC) in which LMW-PTP was transiently inactivated, corroborated with the transient phosphorylation of Tyr857 at the active site of PDGF receptor and the downstream signaling components of Akt and ERK1/2. In contrast, LMW-PTP activity in PDGF-stimulated LEC from TTase(-/-) mice was progressively lost, concomitant with the high basal and sustained high phosphorylation levels at Tyr857, Akt and ERK1/2. We conclude that the reversible LMW-PTP activity regulated by ROS-mediated oxidation and TTase/GSH reduction is the likely mechanism of redox signaling in lens epithelial cells." @default.
• W2079781775 created "2016-06-24" @default.
• W2079781775 creator A5028508794 @default.
• W2079781775 creator A5028809152 @default.
• W2079781775 creator A5070253550 @default.
• W2079781775 creator A5073662759 @default.
• W2079781775 creator A5080113233 @default.
• W2079781775 creator A5084482028 @default.
• W2079781775 date "2007-05-01" @default.
• W2079781775 modified "2023-09-23" @default.
• W2079781775 title "Low molecular weight protein tyrosine phosphatase (LMW-PTP) and its possible physiological functions of redox signaling in the eye lens" @default.
• W2079781775 cites W1966697925 @default.
• W2079781775 cites W1975282307 @default.
• W2079781775 cites W1975587480 @default.
• W2079781775 cites W1978658307 @default.
• W2079781775 cites W2004356154 @default.
• W2079781775 cites W2005028155 @default.
• W2079781775 cites W2005258127 @default.
• W2079781775 cites W2011896510 @default.
• W2079781775 cites W2012116939 @default.
• W2079781775 cites W2019243604 @default.
• W2079781775 cites W2021270113 @default.
• W2079781775 cites W2029048847 @default.
• W2079781775 cites W2031488897 @default.
• W2079781775 cites W2037927361 @default.
• W2079781775 cites W2041991976 @default.
• W2079781775 cites W2042710043 @default.
• W2079781775 cites W2056882459 @default.
• W2079781775 cites W2062055994 @default.
• W2079781775 cites W2079112933 @default.
• W2079781775 cites W2084173287 @default.
• W2079781775 cites W2087018355 @default.
• W2079781775 cites W2103650142 @default.
• W2079781775 cites W2104251051 @default.
• W2079781775 cites W2111160871 @default.
• W2079781775 cites W2119278581 @default.
• W2079781775 cites W2129473990 @default.
• W2079781775 cites W2139783067 @default.
• W2079781775 cites W2163354764 @default.
• W2079781775 cites W40624139 @default.
• W2079781775 cites W4211126501 @default.
• W2079781775 cites W4232534952 @default.
• W2079781775 doi "https://doi.org/10.1016/j.bbapap.2007.03.001" @default.
• W2079781775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1940231" @default.
• W2079781775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428749" @default.
• W2079781775 hasPublicationYear "2007" @default.
• W2079781775 type Work @default.
• W2079781775 sameAs 2079781775 @default.
• W2079781775 citedByCount "23" @default.
• W2079781775 countsByYear W20797817752012 @default.
• W2079781775 countsByYear W20797817752013 @default.
• W2079781775 countsByYear W20797817752014 @default.
• W2079781775 countsByYear W20797817752016 @default.
• W2079781775 countsByYear W20797817752018 @default.
• W2079781775 countsByYear W20797817752019 @default.
• W2079781775 countsByYear W20797817752021 @default.
• W2079781775 countsByYear W20797817752022 @default.
• W2079781775 crossrefType "journal-article" @default.
• W2079781775 hasAuthorship W2079781775A5028508794 @default.
• W2079781775 hasAuthorship W2079781775A5028809152 @default.
• W2079781775 hasAuthorship W2079781775A5070253550 @default.
• W2079781775 hasAuthorship W2079781775A5073662759 @default.
• W2079781775 hasAuthorship W2079781775A5080113233 @default.
• W2079781775 hasAuthorship W2079781775A5084482028 @default.
• W2079781775 hasBestOaLocation W20797817752 @default.
• W2079781775 hasConcept C101544691 @default.
• W2079781775 hasConcept C11960822 @default.
• W2079781775 hasConcept C153911025 @default.
• W2079781775 hasConcept C170493617 @default.
• W2079781775 hasConcept C178666793 @default.
• W2079781775 hasConcept C180361614 @default.
• W2079781775 hasConcept C185592680 @default.
• W2079781775 hasConcept C2775960820 @default.
• W2079781775 hasConcept C2776165026 @default.
• W2079781775 hasConcept C2777553839 @default.
• W2079781775 hasConcept C55493867 @default.
• W2079781775 hasConcept C62478195 @default.
• W2079781775 hasConcept C75217442 @default.
• W2079781775 hasConcept C85528070 @default.
• W2079781775 hasConcept C86803240 @default.
• W2079781775 hasConcept C95444343 @default.
• W2079781775 hasConceptScore W2079781775C101544691 @default.
• W2079781775 hasConceptScore W2079781775C11960822 @default.
• W2079781775 hasConceptScore W2079781775C153911025 @default.
• W2079781775 hasConceptScore W2079781775C170493617 @default.
• W2079781775 hasConceptScore W2079781775C178666793 @default.
• W2079781775 hasConceptScore W2079781775C180361614 @default.
• W2079781775 hasConceptScore W2079781775C185592680 @default.
• W2079781775 hasConceptScore W2079781775C2775960820 @default.
• W2079781775 hasConceptScore W2079781775C2776165026 @default.
• W2079781775 hasConceptScore W2079781775C2777553839 @default.
• W2079781775 hasConceptScore W2079781775C55493867 @default.
• W2079781775 hasConceptScore W2079781775C62478195 @default.
• W2079781775 hasConceptScore W2079781775C75217442 @default.
• W2079781775 hasConceptScore W2079781775C85528070 @default.
• W2079781775 hasConceptScore W2079781775C86803240 @default.
• W2079781775 hasConceptScore W2079781775C95444343 @default.
• W2079781775 hasIssue "5" @default.

• next