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• W2079782303 abstract "Short-term synaptic depression mainly reflects the depletion of the readily releasable pool (RRP) of quanta. Its dynamics, and especially the replenishment rate of the RRP, are still not well characterized in spite of decades of investigation. Main reason is that the vesicular storage and release system is treated as time-independent. If it is time-dependent all parameters thus estimated become problematic. Indeed the reports about how prolonged stimulation affects the dynamics are contradictory. To study this, we used patterned stimulation on the Schaeffer collateral fiber pathway and model-fitting of the excitatory post-synaptic currents (EPSC) recorded from CA1 neurons in rat hippocampal slices. The parameters of a vesicular storage and release model with two pools were estimated by minimizing the squared difference between the ESPC amplitudes and simulated model output. This yields the 'basic' parameters (release coupling, replenishment coupling and RRP size) that underlie the 'derived' and commonly used parameters (fractional release and replenishment rate). The fractional release increases when [Ca(++)]o is raised, whereas the replenishment rate is [Ca(++)]o independent. Fractional release rises because release coupling increases, and the RRP becomes less able to contain quanta. During prolonged stimulation, the fractional release remains generally unaltered, whereas the replenishment rate decreases down to ~10 % of its initial value with a decay time of ~15 s, and this decrease in the replenishment rate significantly contributes to synaptic depression. In conclusion, the fractional release is [Ca(++)]o-dependent and stimulation-independent, whereas the replenishment rate is [Ca(++)]o-independent and stimulation-dependent." @default.
• W2079782303 created "2016-06-24" @default.
• W2079782303 creator A5017905383 @default.
• W2079782303 creator A5044456642 @default.
• W2079782303 date "2012-12-14" @default.
• W2079782303 modified "2023-09-24" @default.
• W2079782303 title "Synaptic activity slows vesicular replenishment at excitatory synapses of rat hippocampus" @default.
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• W2079782303 doi "https://doi.org/10.1007/s11571-012-9232-y" @default.
• W2079782303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595427" @default.
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• W2079782303 hasPublicationYear "2012" @default.
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