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- W2079786079 abstract "Abstract Background: the optimal particle size of a β 2 -mimetic aerosol is not known. Methods: eight stable asthmatics with a FEV 1 (forced expiratory volume) of 72% of the predicted value inhaled three types of monodisperse salbutamol aerosols, with particle sizes of 1.5, 2.8 and 5 μm, respectively, and a placebo aerosol. The volunteers inhaled cumulative dosages of 5, 10, 20 and 40 μg salbutamol, after which lung function improvement was determined. The four resulting dose-response curves (one for each type of aerosol) were analysed with repeated measurements ANOVA. Results: for the FEV 1 and the MEF 75/50/25 (maximum expiratory flow) the 2.8 μm aerosol induced a significantly better dilation than the 5 μm aerosol. In the case of the PEF (peak expiratory flow) the 1.5 μm aerosol elicited a significantly smaller improvement than the 2.8 μm aerosol. No particle size effect was noticeable in the case of the VC (vital capacity), FVC (forced vital capacity) and the R tot . Conclusions: in mild asthmatics the particle size of choice for a β 2 -mimetic aerosol should be around 2.8 μm." @default.
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- W2079786079 date "1994-07-01" @default.
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- W2079786079 title "The optimal particle size for β-adrenergic aerosols in mild asthmatics" @default.
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- W2079786079 doi "https://doi.org/10.1016/0378-5173(94)90436-7" @default.
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