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• W2079786622 abstract "Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 microg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology." @default.
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• W2079786622 date "2005-01-01" @default.
• W2079786622 modified "2023-09-26" @default.
• W2079786622 title "Magnetomotive contrast for in vivo optical coherence tomography" @default.
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• W2079786622 doi "https://doi.org/10.1364/opex.13.006597" @default.
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