Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079786873> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2079786873 endingPage "6441" @default.
- W2079786873 startingPage "6437" @default.
- W2079786873 abstract "The gene for Huntington disease (HD) has been localized to the distal portion of the short arm of human chromosome 4 by linkage analysis. Currently, the two closest DNA markers are D4S10 (G8), located approximately equal to 3 centimorgans centromeric to HD, and D4S43 (C4H), positioned 0-1.5 centimorgans from HD. In an effort to move closer to the HD gene, with the eventual goal of identifying the gene itself, we have applied the technique of chromosome jumping to this region. A 200-kilobase jumping library has been constructed, and a jump from D4S10 has been obtained and its approximate distance verified by pulsed field gel electrophoresis. Two restriction fragment length polymorphisms have been identified at the jump locus, which is denoted D4S81. Linkage analysis of previously identified recombinants between D4S10 and HD or D4S10 and D4S43 shows that in two of five events the jump has crossed the recombination points. This unequivocally orients D4S10 and D4S81 on the chromosome, provides additional markers for HD, and suggests that recombination frequency in this region of chromosome 4 may be increased, so that the physical distance from D4S10 to HD may not be as large as originally suspected." @default.
- W2079786873 created "2016-06-24" @default.
- W2079786873 creator A5031300278 @default.
- W2079786873 creator A5035081543 @default.
- W2079786873 creator A5044329623 @default.
- W2079786873 creator A5049147964 @default.
- W2079786873 creator A5061114231 @default.
- W2079786873 creator A5062252450 @default.
- W2079786873 creator A5068242165 @default.
- W2079786873 date "1988-09-01" @default.
- W2079786873 modified "2023-10-14" @default.
- W2079786873 title "Chromosome jumping from D4S10 (G8) toward the Huntington disease gene." @default.
- W2079786873 cites W1026225774 @default.
- W2079786873 cites W1440597130 @default.
- W2079786873 cites W1514959625 @default.
- W2079786873 cites W158583221 @default.
- W2079786873 cites W1600691108 @default.
- W2079786873 cites W1964094689 @default.
- W2079786873 cites W1967721661 @default.
- W2079786873 cites W1969010806 @default.
- W2079786873 cites W1969521411 @default.
- W2079786873 cites W1970087350 @default.
- W2079786873 cites W1970818972 @default.
- W2079786873 cites W1974909599 @default.
- W2079786873 cites W2000878263 @default.
- W2079786873 cites W2004928211 @default.
- W2079786873 cites W2014669590 @default.
- W2079786873 cites W2017654217 @default.
- W2079786873 cites W2020023927 @default.
- W2079786873 cites W2021608281 @default.
- W2079786873 cites W2028131696 @default.
- W2079786873 cites W2029611498 @default.
- W2079786873 cites W2052950286 @default.
- W2079786873 cites W2076899783 @default.
- W2079786873 cites W2114639593 @default.
- W2079786873 cites W2114999674 @default.
- W2079786873 cites W2142447030 @default.
- W2079786873 cites W2266315341 @default.
- W2079786873 cites W84692197 @default.
- W2079786873 doi "https://doi.org/10.1073/pnas.85.17.6437" @default.
- W2079786873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/281987" @default.
- W2079786873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2901098" @default.
- W2079786873 hasPublicationYear "1988" @default.
- W2079786873 type Work @default.
- W2079786873 sameAs 2079786873 @default.
- W2079786873 citedByCount "33" @default.
- W2079786873 countsByYear W20797868732012 @default.
- W2079786873 countsByYear W20797868732013 @default.
- W2079786873 crossrefType "journal-article" @default.
- W2079786873 hasAuthorship W2079786873A5031300278 @default.
- W2079786873 hasAuthorship W2079786873A5035081543 @default.
- W2079786873 hasAuthorship W2079786873A5044329623 @default.
- W2079786873 hasAuthorship W2079786873A5049147964 @default.
- W2079786873 hasAuthorship W2079786873A5061114231 @default.
- W2079786873 hasAuthorship W2079786873A5062252450 @default.
- W2079786873 hasAuthorship W2079786873A5068242165 @default.
- W2079786873 hasBestOaLocation W20797868732 @default.
- W2079786873 hasConcept C104317684 @default.
- W2079786873 hasConcept C122735190 @default.
- W2079786873 hasConcept C142870003 @default.
- W2079786873 hasConcept C153911025 @default.
- W2079786873 hasConcept C187296825 @default.
- W2079786873 hasConcept C30481170 @default.
- W2079786873 hasConcept C54355233 @default.
- W2079786873 hasConcept C84597430 @default.
- W2079786873 hasConcept C86803240 @default.
- W2079786873 hasConceptScore W2079786873C104317684 @default.
- W2079786873 hasConceptScore W2079786873C122735190 @default.
- W2079786873 hasConceptScore W2079786873C142870003 @default.
- W2079786873 hasConceptScore W2079786873C153911025 @default.
- W2079786873 hasConceptScore W2079786873C187296825 @default.
- W2079786873 hasConceptScore W2079786873C30481170 @default.
- W2079786873 hasConceptScore W2079786873C54355233 @default.
- W2079786873 hasConceptScore W2079786873C84597430 @default.
- W2079786873 hasConceptScore W2079786873C86803240 @default.
- W2079786873 hasIssue "17" @default.
- W2079786873 hasLocation W20797868731 @default.
- W2079786873 hasLocation W20797868732 @default.
- W2079786873 hasLocation W20797868733 @default.
- W2079786873 hasLocation W20797868734 @default.
- W2079786873 hasOpenAccess W2079786873 @default.
- W2079786873 hasPrimaryLocation W20797868731 @default.
- W2079786873 hasRelatedWork W114113623 @default.
- W2079786873 hasRelatedWork W120968873 @default.
- W2079786873 hasRelatedWork W135128205 @default.
- W2079786873 hasRelatedWork W1483574007 @default.
- W2079786873 hasRelatedWork W1979984261 @default.
- W2079786873 hasRelatedWork W2019648484 @default.
- W2079786873 hasRelatedWork W2066363648 @default.
- W2079786873 hasRelatedWork W2132644372 @default.
- W2079786873 hasRelatedWork W2156318738 @default.
- W2079786873 hasRelatedWork W2304819584 @default.
- W2079786873 hasVolume "85" @default.
- W2079786873 isParatext "false" @default.
- W2079786873 isRetracted "false" @default.
- W2079786873 magId "2079786873" @default.
- W2079786873 workType "article" @default.