FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079787008> ?p ?o ?g. }

• W2079787008 endingPage "6245" @default.
• W2079787008 startingPage "6242" @default.
• W2079787008 abstract "Starting from the initial bis-anilinopyrimidine 1, good potency against EphB4 was retained when benzodioxole at C-4 was replaced by an indazole. The key interactions of the indazole with the protein were characterised by crystallographic studies. Further optimisation led to compound 20, a potent inhibitor of the EphB4 and Src kinases with good pharmacokinetics in various preclinical species and high fraction unbound in plasma. Compound 20 may be used as a tool for evaluating the potential of EphB4 kinase inhibitors in vivo." @default.
• W2079787008 created "2016-06-24" @default.
• W2079787008 creator A5004782001 @default.
• W2079787008 creator A5020485412 @default.
• W2079787008 creator A5026352956 @default.
• W2079787008 creator A5033356973 @default.
• W2079787008 creator A5043774187 @default.
• W2079787008 creator A5049197685 @default.
• W2079787008 creator A5050515713 @default.
• W2079787008 creator A5066532314 @default.
• W2079787008 creator A5068310819 @default.
• W2079787008 creator A5068952265 @default.
• W2079787008 date "2010-11-01" @default.
• W2079787008 modified "2023-10-11" @default.
• W2079787008 title "Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors" @default.
• W2079787008 cites W1973648086 @default.
• W2079787008 cites W1980819464 @default.
• W2079787008 cites W1982550220 @default.
• W2079787008 cites W1983392133 @default.
• W2079787008 cites W1992187858 @default.
• W2079787008 cites W1997670728 @default.
• W2079787008 cites W2000601996 @default.
• W2079787008 cites W2001879388 @default.
• W2079787008 cites W2001954506 @default.
• W2079787008 cites W2019839071 @default.
• W2079787008 cites W2021277288 @default.
• W2079787008 cites W2028508216 @default.
• W2079787008 cites W2035595755 @default.
• W2079787008 cites W2038840577 @default.
• W2079787008 cites W2041905383 @default.
• W2079787008 cites W2049726262 @default.
• W2079787008 cites W2069127863 @default.
• W2079787008 cites W2093842873 @default.
• W2079787008 cites W2107281669 @default.
• W2079787008 cites W2117819606 @default.
• W2079787008 cites W2140120206 @default.
• W2079787008 cites W2144081223 @default.
• W2079787008 cites W2146363635 @default.
• W2079787008 cites W2162876548 @default.
• W2079787008 cites W4255240474 @default.
• W2079787008 doi "https://doi.org/10.1016/j.bmcl.2010.08.100" @default.
• W2079787008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20850301" @default.
• W2079787008 hasPublicationYear "2010" @default.
• W2079787008 type Work @default.
• W2079787008 sameAs 2079787008 @default.
• W2079787008 citedByCount "34" @default.
• W2079787008 countsByYear W20797870082012 @default.
• W2079787008 countsByYear W20797870082013 @default.
• W2079787008 countsByYear W20797870082014 @default.
• W2079787008 countsByYear W20797870082015 @default.
• W2079787008 countsByYear W20797870082016 @default.
• W2079787008 countsByYear W20797870082017 @default.
• W2079787008 countsByYear W20797870082018 @default.
• W2079787008 countsByYear W20797870082019 @default.
• W2079787008 countsByYear W20797870082020 @default.
• W2079787008 countsByYear W20797870082022 @default.
• W2079787008 crossrefType "journal-article" @default.
• W2079787008 hasAuthorship W2079787008A5004782001 @default.
• W2079787008 hasAuthorship W2079787008A5020485412 @default.
• W2079787008 hasAuthorship W2079787008A5026352956 @default.
• W2079787008 hasAuthorship W2079787008A5033356973 @default.
• W2079787008 hasAuthorship W2079787008A5043774187 @default.
• W2079787008 hasAuthorship W2079787008A5049197685 @default.
• W2079787008 hasAuthorship W2079787008A5050515713 @default.
• W2079787008 hasAuthorship W2079787008A5066532314 @default.
• W2079787008 hasAuthorship W2079787008A5068310819 @default.
• W2079787008 hasAuthorship W2079787008A5068952265 @default.
• W2079787008 hasConcept C108636557 @default.
• W2079787008 hasConcept C121608353 @default.
• W2079787008 hasConcept C150903083 @default.
• W2079787008 hasConcept C184235292 @default.
• W2079787008 hasConcept C185592680 @default.
• W2079787008 hasConcept C193042331 @default.
• W2079787008 hasConcept C202751555 @default.
• W2079787008 hasConcept C207001950 @default.
• W2079787008 hasConcept C2776980637 @default.
• W2079787008 hasConcept C2778820342 @default.
• W2079787008 hasConcept C2780591553 @default.
• W2079787008 hasConcept C42362537 @default.
• W2079787008 hasConcept C54355233 @default.
• W2079787008 hasConcept C55493867 @default.
• W2079787008 hasConcept C57992300 @default.
• W2079787008 hasConcept C62478195 @default.
• W2079787008 hasConcept C71240020 @default.
• W2079787008 hasConcept C86803240 @default.
• W2079787008 hasConcept C98274493 @default.
• W2079787008 hasConceptScore W2079787008C108636557 @default.
• W2079787008 hasConceptScore W2079787008C121608353 @default.
• W2079787008 hasConceptScore W2079787008C150903083 @default.
• W2079787008 hasConceptScore W2079787008C184235292 @default.
• W2079787008 hasConceptScore W2079787008C185592680 @default.
• W2079787008 hasConceptScore W2079787008C193042331 @default.
• W2079787008 hasConceptScore W2079787008C202751555 @default.
• W2079787008 hasConceptScore W2079787008C207001950 @default.
• W2079787008 hasConceptScore W2079787008C2776980637 @default.
• W2079787008 hasConceptScore W2079787008C2778820342 @default.
• W2079787008 hasConceptScore W2079787008C2780591553 @default.
• W2079787008 hasConceptScore W2079787008C42362537 @default.

• next