Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079787787> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2079787787 endingPage "616" @default.
- W2079787787 startingPage "611" @default.
- W2079787787 abstract "Calcium pectinate beads, a paniculate hydrogel system, is an attractive drug carrier for oral delivery. In this study, a poorly water-soluble model drug indomethacin was incorporated into calcium pectinate beads made of different pectin concentrations, which were produced by an extrusion method. The effect of pectin concentration on bead size, circularity, swelling behavior, and mechanical properties, as well as in vitro drug release profile was investigated. The mechanical properties of calcium pectinate beads were determined by a micromanipulation technique. The drug release profile was measured using a standard British Pharmacopoeia method. It was found that the beads made of higher pectin concentration in general had a less permeable matrix structure and greater mechanical rigidity, although they swelled more after hydration. However, such an effect was not significant when the pectin concentration was increased to above 8%. Micromanipulation measurements showed that there was significant relaxation of the force being imposed on single hydrated beads when they were held, but this phenomenon did not occur on dry beads, which means that the force relaxation was dominated by liquid loss from the beads. The rate of the force relaxation was determined, and has been related to the release rate of the model drug entrapped in the calcium pectinate beads." @default.
- W2079787787 created "2016-06-24" @default.
- W2079787787 creator A5008995033 @default.
- W2079787787 creator A5070112948 @default.
- W2079787787 date "2003-01-01" @default.
- W2079787787 modified "2023-10-16" @default.
- W2079787787 title "Mechanical characterization of calcium pectinate hydrogel for controlled drug delivery" @default.
- W2079787787 cites W126201954 @default.
- W2079787787 cites W1968478008 @default.
- W2079787787 cites W1995977958 @default.
- W2079787787 cites W2009008364 @default.
- W2079787787 cites W2020490654 @default.
- W2079787787 cites W2035655254 @default.
- W2079787787 cites W2048829256 @default.
- W2079787787 cites W2053110727 @default.
- W2079787787 cites W2055976206 @default.
- W2079787787 cites W2153261773 @default.
- W2079787787 cites W2573699296 @default.
- W2079787787 doi "https://doi.org/10.2298/hemind0312611c" @default.
- W2079787787 hasPublicationYear "2003" @default.
- W2079787787 type Work @default.
- W2079787787 sameAs 2079787787 @default.
- W2079787787 citedByCount "5" @default.
- W2079787787 countsByYear W20797877872016 @default.
- W2079787787 countsByYear W20797877872019 @default.
- W2079787787 countsByYear W20797877872021 @default.
- W2079787787 countsByYear W20797877872023 @default.
- W2079787787 crossrefType "journal-article" @default.
- W2079787787 hasAuthorship W2079787787A5008995033 @default.
- W2079787787 hasAuthorship W2079787787A5070112948 @default.
- W2079787787 hasBestOaLocation W20797877872 @default.
- W2079787787 hasConcept C109386097 @default.
- W2079787787 hasConcept C127413603 @default.
- W2079787787 hasConcept C159985019 @default.
- W2079787787 hasConcept C163588942 @default.
- W2079787787 hasConcept C171250308 @default.
- W2079787787 hasConcept C178790620 @default.
- W2079787787 hasConcept C185592680 @default.
- W2079787787 hasConcept C192562407 @default.
- W2079787787 hasConcept C2778540859 @default.
- W2079787787 hasConcept C2778713300 @default.
- W2079787787 hasConcept C2778958987 @default.
- W2079787787 hasConcept C2779820397 @default.
- W2079787787 hasConcept C2780756937 @default.
- W2079787787 hasConcept C42360764 @default.
- W2079787787 hasConcept C43617362 @default.
- W2079787787 hasConcept C519063684 @default.
- W2079787787 hasConcept C55493867 @default.
- W2079787787 hasConceptScore W2079787787C109386097 @default.
- W2079787787 hasConceptScore W2079787787C127413603 @default.
- W2079787787 hasConceptScore W2079787787C159985019 @default.
- W2079787787 hasConceptScore W2079787787C163588942 @default.
- W2079787787 hasConceptScore W2079787787C171250308 @default.
- W2079787787 hasConceptScore W2079787787C178790620 @default.
- W2079787787 hasConceptScore W2079787787C185592680 @default.
- W2079787787 hasConceptScore W2079787787C192562407 @default.
- W2079787787 hasConceptScore W2079787787C2778540859 @default.
- W2079787787 hasConceptScore W2079787787C2778713300 @default.
- W2079787787 hasConceptScore W2079787787C2778958987 @default.
- W2079787787 hasConceptScore W2079787787C2779820397 @default.
- W2079787787 hasConceptScore W2079787787C2780756937 @default.
- W2079787787 hasConceptScore W2079787787C42360764 @default.
- W2079787787 hasConceptScore W2079787787C43617362 @default.
- W2079787787 hasConceptScore W2079787787C519063684 @default.
- W2079787787 hasConceptScore W2079787787C55493867 @default.
- W2079787787 hasIssue "12" @default.
- W2079787787 hasLocation W20797877871 @default.
- W2079787787 hasLocation W20797877872 @default.
- W2079787787 hasOpenAccess W2079787787 @default.
- W2079787787 hasPrimaryLocation W20797877871 @default.
- W2079787787 hasRelatedWork W1810968242 @default.
- W2079787787 hasRelatedWork W1973315847 @default.
- W2079787787 hasRelatedWork W1979331942 @default.
- W2079787787 hasRelatedWork W2214207600 @default.
- W2079787787 hasRelatedWork W2365199807 @default.
- W2079787787 hasRelatedWork W2526113930 @default.
- W2079787787 hasRelatedWork W273211323 @default.
- W2079787787 hasRelatedWork W3162173485 @default.
- W2079787787 hasRelatedWork W192007196 @default.
- W2079787787 hasRelatedWork W2484300805 @default.
- W2079787787 hasVolume "57" @default.
- W2079787787 isParatext "false" @default.
- W2079787787 isRetracted "false" @default.
- W2079787787 magId "2079787787" @default.
- W2079787787 workType "article" @default.