FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079787847> ?p ?o ?g. }

• W2079787847 endingPage "190" @default.
• W2079787847 startingPage "176" @default.
• W2079787847 abstract "In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particularly suitable for long-lasting experiments. The drug exerted profound but reversible modifications of ERG records: (1) a dose-dependent increase of the amplitude and duration of the chemically isolated late receptor potential (LRP), (2) a partial unmasking of LRP, (3) a strong potentiation of the LRP-unmasking effect of low temperature, (4) a potentiation of light adaptation effects, and (5) a strong potentiation of the post-illumination hyperexcitability. The effects were explicable as due to a strong phosphodiesterase (PDE) inhibiting, cyclic guanosine monophosphate (cGMP) promoting, action of the drug. The effects were considerably stronger, or even of opposite sign, in comparison to those of the chemically related theophylline. PPF did not seriously affect the ERG c-wave originating in the pigment epithelium. The results suggested that the effects of PPF on vision may not seriously hamper the therapeutic use of the drug. They indicated, on the other hand, that PPF was a retinoactive drug of potential usefulness in the exploration of the complex biochemical events underlying visual transduction." @default.
• W2079787847 created "2016-06-24" @default.
• W2079787847 creator A5025242150 @default.
• W2079787847 creator A5025993289 @default.
• W2079787847 creator A5042300935 @default.
• W2079787847 creator A5044271401 @default.
• W2079787847 date "2000-06-01" @default.
• W2079787847 modified "2023-09-26" @default.
• W2079787847 title "Effects of xanthine derivatives on electroretinographic responsiveness" @default.
• W2079787847 cites W1596961135 @default.
• W2079787847 cites W1966562971 @default.
• W2079787847 cites W1968488417 @default.
• W2079787847 cites W1978478244 @default.
• W2079787847 cites W1980187745 @default.
• W2079787847 cites W1980312037 @default.
• W2079787847 cites W1990571707 @default.
• W2079787847 cites W1991394602 @default.
• W2079787847 cites W1992622984 @default.
• W2079787847 cites W1997771076 @default.
• W2079787847 cites W2008719474 @default.
• W2079787847 cites W2009940405 @default.
• W2079787847 cites W2012794847 @default.
• W2079787847 cites W2014426699 @default.
• W2079787847 cites W2018991140 @default.
• W2079787847 cites W2019157571 @default.
• W2079787847 cites W2033869755 @default.
• W2079787847 cites W2038509428 @default.
• W2079787847 cites W205588752 @default.
• W2079787847 cites W2068675229 @default.
• W2079787847 cites W2073909805 @default.
• W2079787847 cites W2079129494 @default.
• W2079787847 cites W2083947504 @default.
• W2079787847 cites W2086854267 @default.
• W2079787847 cites W2100445054 @default.
• W2079787847 cites W2147638276 @default.
• W2079787847 cites W2151035819 @default.
• W2079787847 cites W2162709160 @default.
• W2079787847 cites W2170762776 @default.
• W2079787847 doi "https://doi.org/10.1016/s0006-8993(00)02328-3" @default.
• W2079787847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10854570" @default.
• W2079787847 hasPublicationYear "2000" @default.
• W2079787847 type Work @default.
• W2079787847 sameAs 2079787847 @default.
• W2079787847 citedByCount "2" @default.
• W2079787847 countsByYear W20797878472015 @default.
• W2079787847 crossrefType "journal-article" @default.
• W2079787847 hasAuthorship W2079787847A5025242150 @default.
• W2079787847 hasAuthorship W2079787847A5025993289 @default.
• W2079787847 hasAuthorship W2079787847A5042300935 @default.
• W2079787847 hasAuthorship W2079787847A5044271401 @default.
• W2079787847 hasConcept C103796816 @default.
• W2079787847 hasConcept C12554922 @default.
• W2079787847 hasConcept C169760540 @default.
• W2079787847 hasConcept C170493617 @default.
• W2079787847 hasConcept C181199279 @default.
• W2079787847 hasConcept C185263204 @default.
• W2079787847 hasConcept C185592680 @default.
• W2079787847 hasConcept C25274449 @default.
• W2079787847 hasConcept C2778095195 @default.
• W2079787847 hasConcept C2779113765 @default.
• W2079787847 hasConcept C2779470414 @default.
• W2079787847 hasConcept C2780827179 @default.
• W2079787847 hasConcept C55493867 @default.
• W2079787847 hasConcept C62826618 @default.
• W2079787847 hasConcept C86803240 @default.
• W2079787847 hasConcept C98274493 @default.
• W2079787847 hasConceptScore W2079787847C103796816 @default.
• W2079787847 hasConceptScore W2079787847C12554922 @default.
• W2079787847 hasConceptScore W2079787847C169760540 @default.
• W2079787847 hasConceptScore W2079787847C170493617 @default.
• W2079787847 hasConceptScore W2079787847C181199279 @default.
• W2079787847 hasConceptScore W2079787847C185263204 @default.
• W2079787847 hasConceptScore W2079787847C185592680 @default.
• W2079787847 hasConceptScore W2079787847C25274449 @default.
• W2079787847 hasConceptScore W2079787847C2778095195 @default.
• W2079787847 hasConceptScore W2079787847C2779113765 @default.
• W2079787847 hasConceptScore W2079787847C2779470414 @default.
• W2079787847 hasConceptScore W2079787847C2780827179 @default.
• W2079787847 hasConceptScore W2079787847C55493867 @default.
• W2079787847 hasConceptScore W2079787847C62826618 @default.
• W2079787847 hasConceptScore W2079787847C86803240 @default.
• W2079787847 hasConceptScore W2079787847C98274493 @default.
• W2079787847 hasIssue "2" @default.
• W2079787847 hasLocation W20797878471 @default.
• W2079787847 hasLocation W20797878472 @default.
• W2079787847 hasOpenAccess W2079787847 @default.
• W2079787847 hasPrimaryLocation W20797878471 @default.
• W2079787847 hasRelatedWork W1977831885 @default.
• W2079787847 hasRelatedWork W198144718 @default.
• W2079787847 hasRelatedWork W2019567469 @default.
• W2079787847 hasRelatedWork W2040024317 @default.
• W2079787847 hasRelatedWork W2044480037 @default.
• W2079787847 hasRelatedWork W2079787847 @default.
• W2079787847 hasRelatedWork W2106068640 @default.
• W2079787847 hasRelatedWork W2339175250 @default.
• W2079787847 hasRelatedWork W2412004967 @default.
• W2079787847 hasRelatedWork W2610659101 @default.
• W2079787847 hasVolume "868" @default.

• next