FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079788535> ?p ?o ?g. }

• W2079788535 endingPage "e0120702" @default.
• W2079788535 startingPage "e0120702" @default.
• W2079788535 abstract "The ability to survive stressful conditions is important for every living cell. Certain stresses not only affect the current well-being of cells but may also have far-reaching consequences. Uncurbed oxidative stress can cause DNA damage and decrease cell survival and/or increase mutation rates, and certain substances that generate oxidative damage in the cell mainly act on DNA. Radiomimetic zeocin causes oxidative damage in DNA, predominantly by inducing single- or double-strand breaks. Such lesions can lead to chromosomal rearrangements, especially in diploid cells, in which the two sets of chromosomes facilitate excessive and deleterious recombination. In a global screen for zeocin-oversensitive mutants, we selected 133 genes whose deletion reduces the survival of zeocin-treated diploid Saccharomyces cerevisiae cells. The screen revealed numerous genes associated with stress responses, DNA repair genes, cell cycle progression genes, and chromatin remodeling genes. Notably, the screen also demonstrated the involvement of the vesicular trafficking system in cellular protection against DNA damage. The analyses indicated the importance of vesicular system integrity in various pathways of cellular protection from zeocin-dependent damage, including detoxification and a direct or transitional role in genome maintenance processes that remains unclear. The data showed that deleting genes involved in vesicular trafficking may lead to Rad52 focus accumulation and changes in total DNA content or even cell ploidy alterations, and such deletions may preclude proper DNA repair after zeocin treatment. We postulate that functional vesicular transport is crucial for sustaining an integral genome. We believe that the identification of numerous new genes implicated in genome restoration after genotoxic oxidative stress combined with the detected link between vesicular trafficking and genome integrity will reveal novel molecular processes involved in genome stability in diploid cells." @default.
• W2079788535 created "2016-06-24" @default.
• W2079788535 creator A5009795084 @default.
• W2079788535 creator A5012993070 @default.
• W2079788535 creator A5030025785 @default.
• W2079788535 creator A5056513144 @default.
• W2079788535 creator A5081581837 @default.
• W2079788535 date "2015-03-10" @default.
• W2079788535 modified "2023-10-18" @default.
• W2079788535 title "A Genomic Screen Revealing the Importance of Vesicular Trafficking Pathways in Genome Maintenance and Protection against Genotoxic Stress in Diploid Saccharomyces cerevisiae Cells" @default.
• W2079788535 cites W1480404031 @default.
• W2079788535 cites W1491121534 @default.
• W2079788535 cites W1513084652 @default.
• W2079788535 cites W1563504653 @default.
• W2079788535 cites W1629989746 @default.
• W2079788535 cites W1967685941 @default.
• W2079788535 cites W1970250905 @default.
• W2079788535 cites W1978411151 @default.
• W2079788535 cites W1978590580 @default.
• W2079788535 cites W1982367970 @default.
• W2079788535 cites W1983458506 @default.
• W2079788535 cites W1985112184 @default.
• W2079788535 cites W1990833847 @default.
• W2079788535 cites W1999196262 @default.
• W2079788535 cites W2001381163 @default.
• W2079788535 cites W2002454928 @default.
• W2079788535 cites W2005353346 @default.
• W2079788535 cites W2006377598 @default.
• W2079788535 cites W2007710180 @default.
• W2079788535 cites W2008077045 @default.
• W2079788535 cites W2008953900 @default.
• W2079788535 cites W2011664175 @default.
• W2079788535 cites W2012243695 @default.
• W2079788535 cites W2012870736 @default.
• W2079788535 cites W2013767951 @default.
• W2079788535 cites W2014946189 @default.
• W2079788535 cites W2019255805 @default.
• W2079788535 cites W2020476697 @default.
• W2079788535 cites W2024172421 @default.
• W2079788535 cites W2024893538 @default.
• W2079788535 cites W2025972514 @default.
• W2079788535 cites W2026143081 @default.
• W2079788535 cites W2026148775 @default.
• W2079788535 cites W2028774533 @default.
• W2079788535 cites W2035994249 @default.
• W2079788535 cites W2036304963 @default.
• W2079788535 cites W2036646583 @default.
• W2079788535 cites W2038460929 @default.
• W2079788535 cites W2039712191 @default.
• W2079788535 cites W2039876512 @default.
• W2079788535 cites W2040388392 @default.
• W2079788535 cites W2047741179 @default.
• W2079788535 cites W2048723717 @default.
• W2079788535 cites W2058761693 @default.
• W2079788535 cites W2061179531 @default.
• W2079788535 cites W2063787654 @default.
• W2079788535 cites W2065410880 @default.
• W2079788535 cites W2068246844 @default.
• W2079788535 cites W2069949084 @default.
• W2079788535 cites W2078849711 @default.
• W2079788535 cites W2079664271 @default.
• W2079788535 cites W2083609933 @default.
• W2079788535 cites W2083731894 @default.
• W2079788535 cites W2085992142 @default.
• W2079788535 cites W2087469797 @default.
• W2079788535 cites W2087788529 @default.
• W2079788535 cites W2088962538 @default.
• W2079788535 cites W2092899154 @default.
• W2079788535 cites W2093048712 @default.
• W2079788535 cites W2093400437 @default.
• W2079788535 cites W2095085201 @default.
• W2079788535 cites W2095557596 @default.
• W2079788535 cites W2096072198 @default.
• W2079788535 cites W2097621660 @default.
• W2079788535 cites W2097747594 @default.
• W2079788535 cites W2100955611 @default.
• W2079788535 cites W2104028218 @default.
• W2079788535 cites W2106490879 @default.
• W2079788535 cites W2106765641 @default.
• W2079788535 cites W2109603605 @default.
• W2079788535 cites W2109821622 @default.
• W2079788535 cites W2110315365 @default.
• W2079788535 cites W2115306772 @default.
• W2079788535 cites W2115369480 @default.
• W2079788535 cites W2119411909 @default.
• W2079788535 cites W2120751014 @default.
• W2079788535 cites W2121708201 @default.
• W2079788535 cites W2122043909 @default.
• W2079788535 cites W2123738381 @default.
• W2079788535 cites W2124037827 @default.
• W2079788535 cites W2125855207 @default.
• W2079788535 cites W2129712803 @default.
• W2079788535 cites W2135650997 @default.
• W2079788535 cites W2139234011 @default.
• W2079788535 cites W2140948740 @default.
• W2079788535 cites W2145010746 @default.
• W2079788535 cites W2146323074 @default.
• W2079788535 cites W2147560129 @default.

• next