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• W2079789322 abstract "A series of cationic cyclic heptapeptides based on polymyxin B have been synthesized for use as permeabilizers of the outer membrane of Gram-negative bacteria. Only analogs with the Dab2-d-Phe3-Leu4-Xxx5 sequence (Xxx = Dab or Orn) showed a synergistic bactericidal effect when combined with conventional antibiotics, indicating that the Dab2 residue plays a critical role in permeation of the outer membrane of Gram-negative bacteria." @default.
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• W2079789322 date "2010-03-01" @default.
• W2079789322 modified "2023-10-18" @default.
• W2079789322 title "Structure–activity relationships of bacterial outer-membrane permeabilizers based on polymyxin B heptapeptides" @default.
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• W2079789322 doi "https://doi.org/10.1016/j.bmcl.2010.01.040" @default.
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