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- W2079789933 abstract "Tolmetin microspheres were prepared by the coacervation process from the ethylcellulose. Microspheres were obtained both in presence and without protecting colloids, such as polyisobutilene (PIB) or ethyl-vinylacetate copolimers (EVA). The effect of these agents on the preparation, drug content, wall thickness, surface morphology, drug dissolution arid release from microspheres, were evaluated. The dissolution rate analysis was carried out also in the presence of a surfactant (Tween 80) at different pH values.In addition, microspheres containing Tolmetin as a core material were submitted to biological tests, in comparison with the free drug, to evaluate upon experimental models the antipyretic activity and the gastric tolerability." @default.
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- W2079789933 date "1992-01-01" @default.
- W2079789933 modified "2023-09-27" @default.
- W2079789933 title "Preparation and Biological Evaluation of Ethylcellulose Microspheres Containing Tolmetin" @default.
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- W2079789933 doi "https://doi.org/10.3109/03639049209069308" @default.
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