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- W2079789967 abstract "Non-random (skewed) XCI, defined as the preferential inactivation of one of the two X chromosomes in females, has been associated with the physiological selection of “healthy” cells in incidences of mosaicism. We hypothesize that XCI pattern is more non-random in the ICSI newborns because they might have developed from embryos with reduced precursor pools due to a combination of ICSI-related risk factors such as the higher rate of chromosomal abnormalities in the sperm, advanced maternal age, and the invasiveness of the procedure. We propose to use XCI as an indirect assessment of possible incidences of mosaicism (i.e. chromosomal abnormalities in some but not all cells) in ICSI conceptions and compare the pattern of XCI in ICSI newborns to that in the general population. A prospective study. A methylation-based XCI assay was performed on DNA extracted from cord blood from 44 female ICSI newborns with normal karyotypes and 74 female controls (aged 0-19 years). The XCI assay involves methylation-sensitive restriction enzyme digestion followed by PCR amplification of the differentially methylated CpG sites of the X-linked Androgen Receptor gene. Fisher’s exact test will also be used to statistically detect a difference in the rates of skewed XCI in each group. The mean degree of skewing of XCI was 66.3% and 69.8% for ICSI and control, respectively. An extremely skewed XCI pattern (> 90% skewed) was observed in 5.1% of the ICSI group and 10.8% in the control group, which is not statistically significant (P>0.5). No significant difference was found in XCI patterns between ICSI newborns and controls primarily because our data was preliminary and sample size was insufficient. Although there may indeed be no difference between ICSI and naturally conceptions, further study needs to be done to confirm this." @default.
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- W2079789967 date "2005-09-01" @default.
- W2079789967 modified "2023-09-30" @default.
- W2079789967 title "X-Chromosome Inactivation (XCI) in Newborns Conceived Through Intracytoplasmic Sperm Injection (ICSI)" @default.
- W2079789967 doi "https://doi.org/10.1016/j.fertnstert.2005.07.622" @default.
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