FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079790749> ?p ?o ?g. }

• W2079790749 endingPage "262" @default.
• W2079790749 startingPage "245" @default.
• W2079790749 abstract "The treatment of neuropathic pain is often unsatisfactory. A better understanding of the underlying mechanisms is expected to improve treatment strategies and to develop new treatment options. Multiple animal models have been developed that allow the assessment of behavioral signs of neuropathic pain and the investigation of injury-induced changes in the peripheral and central nervous system. Much of our current knowledge has been generated from animal models that use traumatic nerve injuries to induce neuropathic pain. Behavioral signs in these models mimic symptoms seen in humans suffering from neuropathic pain, including signs of spontaneous pain, thermal and mechanical hyperalgesia. Electrophysiologic recordings in these models have shown that injured primary afferent neurons become hyperexcitable, that is, they show spontaneous activity and ectopic sensitivity to natural stimuli. Not surprisingly, injured neurons show an altered expression of ion channels involved in setting neuronal excitability. Recent research uncovered that uninjured neurons show similar changes, including spontaneous activity, an increased sensitivity to peripheral stimuli, and changes in protein expression. The changes in injured neurons are likely due to alterations in neurotrophic supply. These and processes related to Wallerian degeneration may account for the changes in uninjured neurons. Peripheral nerve injury also leads to changes in the central nervous system. Sensitization of central neurons is an important mechanism of neuropathic pain. Central disinhibition and activation of spinal microglia may contribute to this sensitization." @default.
• W2079790749 created "2016-06-24" @default.
• W2079790749 creator A5077871329 @default.
• W2079790749 creator A5085919942 @default.
• W2079790749 date "2007-12-01" @default.
• W2079790749 modified "2023-09-25" @default.
• W2079790749 title "The Pathophysiology of Neuropathic Pain: A Review of Current Research and Hypotheses" @default.
• W2079790749 cites W1482813429 @default.
• W2079790749 cites W1491409303 @default.
• W2079790749 cites W1496712622 @default.
• W2079790749 cites W1502160133 @default.
• W2079790749 cites W1508375089 @default.
• W2079790749 cites W1526580466 @default.
• W2079790749 cites W1547720366 @default.
• W2079790749 cites W1567615855 @default.
• W2079790749 cites W1568010017 @default.
• W2079790749 cites W1582090951 @default.
• W2079790749 cites W1588041244 @default.
• W2079790749 cites W1589931324 @default.
• W2079790749 cites W1623378741 @default.
• W2079790749 cites W1744651828 @default.
• W2079790749 cites W1748514544 @default.
• W2079790749 cites W1764887409 @default.
• W2079790749 cites W1780663294 @default.
• W2079790749 cites W1794352460 @default.
• W2079790749 cites W1818085992 @default.
• W2079790749 cites W1858482902 @default.
• W2079790749 cites W1873187871 @default.
• W2079790749 cites W1878253384 @default.
• W2079790749 cites W1878468192 @default.
• W2079790749 cites W1899933128 @default.
• W2079790749 cites W1914090025 @default.
• W2079790749 cites W1914763441 @default.
• W2079790749 cites W1952350508 @default.
• W2079790749 cites W1959152155 @default.
• W2079790749 cites W1959229569 @default.
• W2079790749 cites W1963857381 @default.
• W2079790749 cites W1964248709 @default.
• W2079790749 cites W1964497912 @default.
• W2079790749 cites W1964695640 @default.
• W2079790749 cites W1964748039 @default.
• W2079790749 cites W1965102171 @default.
• W2079790749 cites W1965431554 @default.
• W2079790749 cites W1965538993 @default.
• W2079790749 cites W1965866432 @default.
• W2079790749 cites W1966294183 @default.
• W2079790749 cites W1966568440 @default.
• W2079790749 cites W1966671044 @default.
• W2079790749 cites W1967441802 @default.
• W2079790749 cites W1968618759 @default.
• W2079790749 cites W1971748206 @default.
• W2079790749 cites W1971857467 @default.
• W2079790749 cites W1971936787 @default.
• W2079790749 cites W1974107068 @default.
• W2079790749 cites W1974508905 @default.
• W2079790749 cites W1974511524 @default.
• W2079790749 cites W1975220342 @default.
• W2079790749 cites W1975250711 @default.
• W2079790749 cites W1976376877 @default.
• W2079790749 cites W1977051447 @default.
• W2079790749 cites W1978605906 @default.
• W2079790749 cites W1979246434 @default.
• W2079790749 cites W1980369017 @default.
• W2079790749 cites W1980557428 @default.
• W2079790749 cites W1982095811 @default.
• W2079790749 cites W1982793958 @default.
• W2079790749 cites W1982942262 @default.
• W2079790749 cites W1983028276 @default.
• W2079790749 cites W1983997467 @default.
• W2079790749 cites W1984025105 @default.
• W2079790749 cites W1985005927 @default.
• W2079790749 cites W1985425684 @default.
• W2079790749 cites W1985842189 @default.
• W2079790749 cites W1985877156 @default.
• W2079790749 cites W1986715632 @default.
• W2079790749 cites W1987439527 @default.
• W2079790749 cites W1987809797 @default.
• W2079790749 cites W1988343905 @default.
• W2079790749 cites W1990330032 @default.
• W2079790749 cites W1990360679 @default.
• W2079790749 cites W1991550485 @default.
• W2079790749 cites W1992137621 @default.
• W2079790749 cites W1993267237 @default.
• W2079790749 cites W1993578629 @default.
• W2079790749 cites W1994334998 @default.
• W2079790749 cites W1994516788 @default.
• W2079790749 cites W1994523411 @default.
• W2079790749 cites W1994618304 @default.
• W2079790749 cites W1995243137 @default.
• W2079790749 cites W1995398247 @default.
• W2079790749 cites W1996951072 @default.
• W2079790749 cites W1998011990 @default.
• W2079790749 cites W1998467441 @default.
• W2079790749 cites W1998901000 @default.
• W2079790749 cites W2000178071 @default.
• W2079790749 cites W2000500546 @default.
• W2079790749 cites W2002692790 @default.
• W2079790749 cites W2003542915 @default.

• next