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- W2079790761 abstract "We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduced the cellular pH (pHi) dose-dependently. AVP increased cellular cAMP production in a dose-dependent manner. 5 x 10(-6) and 1 x 10(-5) M NEM significantly diminished the AVP-induced increase in cAMP production. 1 x 10(-7) M AVP also increased [Ca2+]i from 111.2 to 189.3 nM, which was significantly reduced by NEM in a dose-dependent manner. These results indicate that H(+)-ATPase participates the cellular action of AVP mediated via the pHi control in renal papillary collecting tubule cells." @default.
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- W2079790761 date "1993-01-01" @default.
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- W2079790761 title "Inhibition by N-ethylmaleimide of H+-ATPase reduces the cellular action of arginine vasopressin in cultured rat renal papillary collecting tubule cells" @default.
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- W2079790761 doi "https://doi.org/10.1016/0024-3205(93)90594-s" @default.
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