FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079791093> ?p ?o ?g. }

• W2079791093 endingPage "4194" @default.
• W2079791093 startingPage "4189" @default.
• W2079791093 abstract "The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitro that may adversely affect viral fitness or replication capacity, which creates a potential rationale for its maintenance once it has been selected by antiviral chemotherapy. However, the relative effectiveness of nucleoside RT inhibitors that are structurally unrelated to 3TC in selecting and/or maintaining M184V has not been investigated. In the present study, we have studied the abilities of a variety of drugs, i.e., zalcitabine (ddC), didanosine (ddI), abacavir (ABC), and the novel nucleoside SPD754, in addition to 3TC, to maintain the presence of M184V in tissue culture and have shown that SPD754, ABC, and 3TC are able to preserve M184V in mixed dual infections consisting of wild-type viruses and clinical isolates which contained the M184V mutation. Moreover, M184V could also be maintained in these cultures when a subtherapeutic concentration of 3TC (i.e., 0.05 microM) was used. In contrast, neither ddI nor ddC was able to maintain M184V to the same extent as the other drugs after 10 weeks of tissue culture in mixtures of wild-type viruses and isolates containing M184V in different proportions." @default.
• W2079791093 created "2016-06-24" @default.
• W2079791093 creator A5029881635 @default.
• W2079791093 creator A5035584213 @default.
• W2079791093 creator A5039168874 @default.
• W2079791093 creator A5052154929 @default.
• W2079791093 creator A5058445557 @default.
• W2079791093 creator A5082776171 @default.
• W2079791093 date "2004-11-01" @default.
• W2079791093 modified "2023-10-18" @default.
• W2079791093 title "Differential Maintenance of the M184V Substitution in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 by Various Nucleoside Antiretroviral Agents in Tissue Culture" @default.
• W2079791093 cites W1635485592 @default.
• W2079791093 cites W1739536295 @default.
• W2079791093 cites W1857344328 @default.
• W2079791093 cites W186337204 @default.
• W2079791093 cites W1930979362 @default.
• W2079791093 cites W1963561607 @default.
• W2079791093 cites W1975150253 @default.
• W2079791093 cites W1977521763 @default.
• W2079791093 cites W1985928587 @default.
• W2079791093 cites W1988889150 @default.
• W2079791093 cites W1996482816 @default.
• W2079791093 cites W1998085351 @default.
• W2079791093 cites W2002108880 @default.
• W2079791093 cites W2008954911 @default.
• W2079791093 cites W2009581957 @default.
• W2079791093 cites W2012842150 @default.
• W2079791093 cites W2026323517 @default.
• W2079791093 cites W2035938088 @default.
• W2079791093 cites W204016963 @default.
• W2079791093 cites W2041335447 @default.
• W2079791093 cites W2044237989 @default.
• W2079791093 cites W2044864734 @default.
• W2079791093 cites W2045953763 @default.
• W2079791093 cites W2046418657 @default.
• W2079791093 cites W2050863727 @default.
• W2079791093 cites W2052540906 @default.
• W2079791093 cites W2056866101 @default.
• W2079791093 cites W2057227263 @default.
• W2079791093 cites W2062388675 @default.
• W2079791093 cites W2064360930 @default.
• W2079791093 cites W2071822666 @default.
• W2079791093 cites W2096494921 @default.
• W2079791093 cites W2099116161 @default.
• W2079791093 cites W2101549718 @default.
• W2079791093 cites W2107138643 @default.
• W2079791093 cites W2108532941 @default.
• W2079791093 cites W2119363545 @default.
• W2079791093 cites W2120762383 @default.
• W2079791093 cites W2122858742 @default.
• W2079791093 cites W2126983724 @default.
• W2079791093 cites W2127518061 @default.
• W2079791093 cites W2129218025 @default.
• W2079791093 cites W2138216643 @default.
• W2079791093 cites W2139502307 @default.
• W2079791093 cites W2140293285 @default.
• W2079791093 cites W2140707155 @default.
• W2079791093 cites W2141304944 @default.
• W2079791093 cites W2141883500 @default.
• W2079791093 cites W2150163022 @default.
• W2079791093 cites W2169635828 @default.
• W2079791093 cites W22123178 @default.
• W2079791093 cites W2322579223 @default.
• W2079791093 cites W2323246380 @default.
• W2079791093 cites W2323368454 @default.
• W2079791093 cites W2331984932 @default.
• W2079791093 cites W2399905123 @default.
• W2079791093 cites W2408860094 @default.
• W2079791093 cites W2416424586 @default.
• W2079791093 cites W2419522998 @default.
• W2079791093 cites W2467424316 @default.
• W2079791093 cites W4246921863 @default.
• W2079791093 doi "https://doi.org/10.1128/aac.48.11.4189-4194.2004" @default.
• W2079791093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/525456" @default.
• W2079791093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15504840" @default.
• W2079791093 hasPublicationYear "2004" @default.
• W2079791093 type Work @default.
• W2079791093 sameAs 2079791093 @default.
• W2079791093 citedByCount "30" @default.
• W2079791093 countsByYear W20797910932012 @default.
• W2079791093 countsByYear W20797910932013 @default.
• W2079791093 countsByYear W20797910932014 @default.
• W2079791093 countsByYear W20797910932017 @default.
• W2079791093 countsByYear W20797910932018 @default.
• W2079791093 countsByYear W20797910932020 @default.
• W2079791093 countsByYear W20797910932021 @default.
• W2079791093 countsByYear W20797910932023 @default.
• W2079791093 crossrefType "journal-article" @default.
• W2079791093 hasAuthorship W2079791093A5029881635 @default.
• W2079791093 hasAuthorship W2079791093A5035584213 @default.
• W2079791093 hasAuthorship W2079791093A5039168874 @default.
• W2079791093 hasAuthorship W2079791093A5052154929 @default.
• W2079791093 hasAuthorship W2079791093A5058445557 @default.
• W2079791093 hasAuthorship W2079791093A5082776171 @default.
• W2079791093 hasBestOaLocation W20797910931 @default.
• W2079791093 hasConcept C104317684 @default.
• W2079791093 hasConcept C142462285 @default.
• W2079791093 hasConcept C156719811 @default.

• next