FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079795132> ?p ?o ?g. }

• W2079795132 endingPage "93" @default.
• W2079795132 startingPage "82" @default.
• W2079795132 abstract "Ospemifene is a selective estrogen receptor modulator (SERM) approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy (VVA) due to menopause. As the first non-hormonal treatment for this indication, the approval of ospemifene represents a significant milestone in postmenopausal women's health. Ospemifene is a triphenylethylene similar in chemical structure to tamoxifen and toremifene. Consistent with other SERMs such as tamoxifen, toremifene, and raloxifene, ospemifene possesses a distinctive mix of estrogenic and antiestrogenic tissue-specific effects in bone, breast tissue, serum lipids, and the vagina. Among the approved SERMs, ospemifene is the only agent with a nearly full estrogen agonist effect on the vaginal epithelium while having neutral to slight estrogenic effects in the endometrium, making ospemifene uniquely suited for the treatment of dyspareunia associated with VVA, also known as atrophic vaginitis, which affects up to 50% of postmenopausal women. This review begins with a brief history of the discovery of ospemifene, its mechanism of action, and its preclinical development, with an emphasis on its tissue-specific effects on bone, breast, uterus and endometrium, serum lipids and vagina. A brief discussion on the genotoxicity of ospemifene compared to tamoxifen and toremifene is included. The focus then shifts to the clinical development of ospemifene from Phase I through Phase III. We will close with the FDA approval of ospemifene and a justification of the future clinical evaluation of ospemifene as a potential breast cancer chemopreventive agent, where several preclinical studies in different rodent breast cancer models strongly suggest ospemifene is as effective as tamoxifen." @default.
• W2079795132 created "2016-06-24" @default.
• W2079795132 creator A5025530600 @default.
• W2079795132 creator A5038173854 @default.
• W2079795132 creator A5090852751 @default.
• W2079795132 date "2014-11-01" @default.
• W2079795132 modified "2023-10-02" @default.
• W2079795132 title "Ospemifene: A first-in-class, non-hormonal selective estrogen receptor modulator approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy" @default.
• W2079795132 cites W1593442063 @default.
• W2079795132 cites W1844666621 @default.
• W2079795132 cites W1918705397 @default.
• W2079795132 cites W1925424309 @default.
• W2079795132 cites W1963570942 @default.
• W2079795132 cites W1963820278 @default.
• W2079795132 cites W1965726545 @default.
• W2079795132 cites W1969487403 @default.
• W2079795132 cites W1976472898 @default.
• W2079795132 cites W1977430857 @default.
• W2079795132 cites W1977572443 @default.
• W2079795132 cites W1981467972 @default.
• W2079795132 cites W1982521833 @default.
• W2079795132 cites W1983801145 @default.
• W2079795132 cites W1984565138 @default.
• W2079795132 cites W1984670037 @default.
• W2079795132 cites W1984925799 @default.
• W2079795132 cites W1988443422 @default.
• W2079795132 cites W1989239843 @default.
• W2079795132 cites W1995584214 @default.
• W2079795132 cites W1997279492 @default.
• W2079795132 cites W1997883187 @default.
• W2079795132 cites W2001507203 @default.
• W2079795132 cites W2002255390 @default.
• W2079795132 cites W2003105846 @default.
• W2079795132 cites W2008549740 @default.
• W2079795132 cites W2010159589 @default.
• W2079795132 cites W2010580958 @default.
• W2079795132 cites W2011732209 @default.
• W2079795132 cites W2011779669 @default.
• W2079795132 cites W2013230144 @default.
• W2079795132 cites W2020547886 @default.
• W2079795132 cites W2028480034 @default.
• W2079795132 cites W2032346244 @default.
• W2079795132 cites W2032958881 @default.
• W2079795132 cites W2034084843 @default.
• W2079795132 cites W2036222013 @default.
• W2079795132 cites W2041083920 @default.
• W2079795132 cites W2041938813 @default.
• W2079795132 cites W2045389096 @default.
• W2079795132 cites W2051474921 @default.
• W2079795132 cites W2054602950 @default.
• W2079795132 cites W2058475235 @default.
• W2079795132 cites W2062244421 @default.
• W2079795132 cites W2062870076 @default.
• W2079795132 cites W2070506018 @default.
• W2079795132 cites W2074344979 @default.
• W2079795132 cites W2081111891 @default.
• W2079795132 cites W2085509695 @default.
• W2079795132 cites W2088121845 @default.
• W2079795132 cites W2089258206 @default.
• W2079795132 cites W2089322530 @default.
• W2079795132 cites W2090570558 @default.
• W2079795132 cites W2098010773 @default.
• W2079795132 cites W2100874814 @default.
• W2079795132 cites W2101738855 @default.
• W2079795132 cites W2107859602 @default.
• W2079795132 cites W2111449140 @default.
• W2079795132 cites W2121454015 @default.
• W2079795132 cites W2130825104 @default.
• W2079795132 cites W2133813353 @default.
• W2079795132 cites W2137792512 @default.
• W2079795132 cites W2139272277 @default.
• W2079795132 cites W2139744884 @default.
• W2079795132 cites W2141647078 @default.
• W2079795132 cites W2144710863 @default.
• W2079795132 cites W2146569020 @default.
• W2079795132 cites W2148979187 @default.
• W2079795132 cites W2150699733 @default.
• W2079795132 cites W2163126741 @default.
• W2079795132 cites W2165198403 @default.
• W2079795132 cites W2271692031 @default.
• W2079795132 cites W2323466156 @default.
• W2079795132 cites W2324114402 @default.
• W2079795132 doi "https://doi.org/10.1016/j.steroids.2014.07.012" @default.
• W2079795132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25087944" @default.
• W2079795132 hasPublicationYear "2014" @default.
• W2079795132 type Work @default.
• W2079795132 sameAs 2079795132 @default.
• W2079795132 citedByCount "33" @default.
• W2079795132 countsByYear W20797951322014 @default.
• W2079795132 countsByYear W20797951322015 @default.
• W2079795132 countsByYear W20797951322016 @default.
• W2079795132 countsByYear W20797951322017 @default.
• W2079795132 countsByYear W20797951322018 @default.
• W2079795132 countsByYear W20797951322019 @default.
• W2079795132 countsByYear W20797951322020 @default.
• W2079795132 countsByYear W20797951322022 @default.
• W2079795132 countsByYear W20797951322023 @default.
• W2079795132 crossrefType "journal-article" @default.

• next