Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079795145> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2079795145 endingPage "56" @default.
- W2079795145 startingPage "51" @default.
- W2079795145 abstract "This study was conducted to determine the pharmacokinetics of the fixed combination antibiotic cefoperazone-sulbactam in patients receiving continuous ambulatory peritoneal dialysis (CAPD). In addition, the pharmacodynamic profile of this combination was determined by the use of mean bactericidal titers against selected bacterial strains. Six noninfected CAPD patients were given a fixed dose of cefoperazone (2 g) and sulbactam (1 g) either intravenously or intraperitoneally over 10 min in a randomized, two-way crossover fashion. The mean peak cefoperazone concentration in serum after intravenous administration was 280.9 micrograms/ml. The mean peak concentration in serum after intraperitoneal cefoperazone administration was 38.9 micrograms/ml and occurred 2 to 4 h postdose. The mean peak sulbactam concentration in serum after intravenous administration was 82.2 micrograms/ml. The mean peak concentration in serum after intraperitoneal sulbactam administration was 24.4 micrograms/ml and occurred at 6 h. The absolute bioavailability of the intraperitoneal dose was 61% for cefoperazone and 70% for sulbactam. Cefoperazone total body and renal clearances were unaffected by renal failure and dialysis. However, both clearance values for sulbactam were reduced markedly. Only intraperitoneal dosing provided peak inhibitory and bactericidal titers in dialysate for all organisms tested. Intravenous dosing provided satisfactory dialysate titers only for very susceptible bacterial strains. End-stage renal disease and CAPD do not alter cefoperazone pharmacokinetics; however, sulbactam dosing may need to be adjusted." @default.
- W2079795145 created "2016-06-24" @default.
- W2079795145 creator A5030159684 @default.
- W2079795145 creator A5032227480 @default.
- W2079795145 creator A5057537941 @default.
- W2079795145 creator A5064800329 @default.
- W2079795145 creator A5082154847 @default.
- W2079795145 creator A5082661947 @default.
- W2079795145 date "1988-01-01" @default.
- W2079795145 modified "2023-09-27" @default.
- W2079795145 title "Pharmacokinetics and pharmacodynamics of cefoperazone-sulbactam in patients on continuous ambulatory peritoneal dialysis" @default.
- W2079795145 cites W1808101289 @default.
- W2079795145 cites W1969776961 @default.
- W2079795145 cites W2007960939 @default.
- W2079795145 cites W2036520108 @default.
- W2079795145 cites W2042092661 @default.
- W2079795145 cites W2068959795 @default.
- W2079795145 cites W2074513663 @default.
- W2079795145 cites W2081096611 @default.
- W2079795145 cites W2089319051 @default.
- W2079795145 cites W2112803227 @default.
- W2079795145 cites W2131370635 @default.
- W2079795145 cites W4211253249 @default.
- W2079795145 cites W4254035527 @default.
- W2079795145 doi "https://doi.org/10.1128/aac.32.1.51" @default.
- W2079795145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/172097" @default.
- W2079795145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3348613" @default.
- W2079795145 hasPublicationYear "1988" @default.
- W2079795145 type Work @default.
- W2079795145 sameAs 2079795145 @default.
- W2079795145 citedByCount "15" @default.
- W2079795145 countsByYear W20797951452021 @default.
- W2079795145 countsByYear W20797951452022 @default.
- W2079795145 crossrefType "journal-article" @default.
- W2079795145 hasAuthorship W2079795145A5030159684 @default.
- W2079795145 hasAuthorship W2079795145A5032227480 @default.
- W2079795145 hasAuthorship W2079795145A5057537941 @default.
- W2079795145 hasAuthorship W2079795145A5064800329 @default.
- W2079795145 hasAuthorship W2079795145A5082154847 @default.
- W2079795145 hasAuthorship W2079795145A5082661947 @default.
- W2079795145 hasBestOaLocation W20797951452 @default.
- W2079795145 hasConcept C111113717 @default.
- W2079795145 hasConcept C112705442 @default.
- W2079795145 hasConcept C126322002 @default.
- W2079795145 hasConcept C139254425 @default.
- W2079795145 hasConcept C192670549 @default.
- W2079795145 hasConcept C2776432923 @default.
- W2079795145 hasConcept C2778478555 @default.
- W2079795145 hasConcept C2779056158 @default.
- W2079795145 hasConcept C2779631663 @default.
- W2079795145 hasConcept C2909406889 @default.
- W2079795145 hasConcept C3019249092 @default.
- W2079795145 hasConcept C42219234 @default.
- W2079795145 hasConcept C501593827 @default.
- W2079795145 hasConcept C71924100 @default.
- W2079795145 hasConcept C86803240 @default.
- W2079795145 hasConcept C89423630 @default.
- W2079795145 hasConcept C94665300 @default.
- W2079795145 hasConcept C98274493 @default.
- W2079795145 hasConceptScore W2079795145C111113717 @default.
- W2079795145 hasConceptScore W2079795145C112705442 @default.
- W2079795145 hasConceptScore W2079795145C126322002 @default.
- W2079795145 hasConceptScore W2079795145C139254425 @default.
- W2079795145 hasConceptScore W2079795145C192670549 @default.
- W2079795145 hasConceptScore W2079795145C2776432923 @default.
- W2079795145 hasConceptScore W2079795145C2778478555 @default.
- W2079795145 hasConceptScore W2079795145C2779056158 @default.
- W2079795145 hasConceptScore W2079795145C2779631663 @default.
- W2079795145 hasConceptScore W2079795145C2909406889 @default.
- W2079795145 hasConceptScore W2079795145C3019249092 @default.
- W2079795145 hasConceptScore W2079795145C42219234 @default.
- W2079795145 hasConceptScore W2079795145C501593827 @default.
- W2079795145 hasConceptScore W2079795145C71924100 @default.
- W2079795145 hasConceptScore W2079795145C86803240 @default.
- W2079795145 hasConceptScore W2079795145C89423630 @default.
- W2079795145 hasConceptScore W2079795145C94665300 @default.
- W2079795145 hasConceptScore W2079795145C98274493 @default.
- W2079795145 hasIssue "1" @default.
- W2079795145 hasLocation W20797951451 @default.
- W2079795145 hasLocation W20797951452 @default.
- W2079795145 hasLocation W20797951453 @default.
- W2079795145 hasOpenAccess W2079795145 @default.
- W2079795145 hasPrimaryLocation W20797951451 @default.
- W2079795145 hasRelatedWork W1998225726 @default.
- W2079795145 hasRelatedWork W2079795145 @default.
- W2079795145 hasRelatedWork W2115168234 @default.
- W2079795145 hasRelatedWork W2121385453 @default.
- W2079795145 hasRelatedWork W2131370635 @default.
- W2079795145 hasRelatedWork W2154001680 @default.
- W2079795145 hasRelatedWork W2334146688 @default.
- W2079795145 hasRelatedWork W2348554012 @default.
- W2079795145 hasRelatedWork W3009942389 @default.
- W2079795145 hasRelatedWork W72306757 @default.
- W2079795145 hasVolume "32" @default.
- W2079795145 isParatext "false" @default.
- W2079795145 isRetracted "false" @default.
- W2079795145 magId "2079795145" @default.
- W2079795145 workType "article" @default.