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• W2079796046 abstract "Differential coexpression analysis usually requires the definition of 'distance' or 'similarity' between measured datasets. Until now, the most common choice is Pearson correlation coefficient. However, Pearson correlation coefficient is sensitive to outliers. Biweight midcorrelation is considered to be a good alternative to Pearson correlation since it is more robust to outliers. In this paper, we introduce to use Biweight Midcorrelation to measure 'similarity' between gene expression profiles, and provide a new approach for gene differential coexpression analysis. Firstly, we calculate the biweight midcorrelation coefficients between all gene pairs. Then, we filter out non-informative correlation pairs using the 'half-thresholding' strategy and calculate the differential coexpression value of gene, The experimental results on simulated data show that the new approach performed better than three previously published differential coexpression analysis (DCEA) methods. Moreover, we use the maximum clique analysis to gene subset included genes identified by our approach and previously reported T2D-related genes, many additional discoveries can be found through our method." @default.
• W2079796046 created "2016-06-24" @default.
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• W2079796046 date "2014-12-01" @default.
• W2079796046 modified "2023-10-16" @default.
• W2079796046 title "Gene differential coexpression analysis based on biweight correlation and maximum clique" @default.
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• W2079796046 doi "https://doi.org/10.1186/1471-2105-15-s15-s3" @default.
• W2079796046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4271563" @default.
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• W2079796046 hasPublicationYear "2014" @default.
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