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• W2079796198 abstract "Background: There are conflicting reports on the expression of cyclooxygenase in Helicobacter pylori infection. Aim: To evaluate the expression of COX-1 and COX-2 in H. pylori gastritis at messenger RNA (mRNA) and protein levels. Methods: Endoscopic gastric biopsies were obtained from patients with non-ulcer dyspepsia. The levels of COX-1 and COX-2 mRNA were compared between H. pylori-infected and uninfected specimens using reverse transcription-polymerase chain reaction. The immunohistochemical findings were correlated with the cellular localization of cyclooxygenase mRNA using in situ hybridization. Results: A total of 40 H. pylori-infected and 40 uninfected specimens were studied. mRNA of COX-2 but not COX-1 was elevated in H. pylori-infected mucosa. COX-1 was localized to the mononuclear inflammatory, endothelial and smooth muscle cells in the lamina propria. COX-2 was barely detectable in uninfected mucosa but was strongly expressed in the foveolar and glandular epithelia in H. pylori gastritis. Conclusion: Cyclooxygenase-1 is expressed in the mononuclear inflammatory, endothelial and smooth muscle cells in the lamina propria irrespective of the H. pylori status. By contrast, H. pylori induces COX-2 expression in the foveolar and glandular epithelia." @default.
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• W2079796198 date "2001-02-05" @default.
• W2079796198 modified "2023-10-14" @default.
• W2079796198 title "Expression and cellular localization of COX-1 and -2 in <i>Helicobacter pylori</i> gastritis" @default.
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• W2079796198 doi "https://doi.org/10.1046/j.1365-2036.2001.00918.x" @default.
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