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- W2079796601 endingPage "2537" @default.
- W2079796601 startingPage "2529" @default.
- W2079796601 abstract "Listeria monocytogenes (L. monocytogenes) can cause fatal brainstem encephalitis in both sheep and humans. Here we review evidence that the bacteria can be incorporated into axons following a primary cycle of replication in macrophages/dendritic cells after subcutaneous injection in projection areas of peripheral neurons. The molecular mechanisms for the rocketing of L. monocytogenes in the cytosol by asymmetric cometic tails and the utility of this phenomenon for bacterial migration intraaxonally both in retro- and in anterograde directions to reach the central nervous system are described. The role of the immune response in the control of L. monocytogenes spread through peripheral neurons is highlighted, and a mechanism by which bacteria may be killed inside infected neurons through a nitric oxide-dependent pathway is pointed out. © 2007 Wiley-Liss, Inc." @default.
- W2079796601 created "2016-06-24" @default.
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- W2079796601 creator A5026937377 @default.
- W2079796601 creator A5052406718 @default.
- W2079796601 creator A5078566025 @default.
- W2079796601 date "2007-01-01" @default.
- W2079796601 modified "2023-10-01" @default.
- W2079796601 title "Axonal transport ofListeria monocytogenes and nerve-cell-induced bacterial killing" @default.
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