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- W2079796654 abstract "Abstract Therapeutic use of cytokines in humans can result in the generation of antibodies that bind to the drug. In order to predict the potential effects of an autoantibody response to recombinant human G-CSF therapy, we developed a novel, reproducible mouse model of anti-G-CSF specific humoral immunity. Two groups of mice were immunized and boosted with mouse G-CSF (mG-CSF) chemically conjugated to either KLH or OVA on an alternating schedule. All mice immunized with the mG-CSF conjugates produced high titer, mG-CSF specific IgG responses that lasted for the length of the study (252 days). Significant neutropenia was concurrent with the rise in anti-mG-CSF IgG titers (p" @default.
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- W2079796654 date "2000-07-01" @default.
- W2079796654 modified "2023-09-27" @default.
- W2079796654 title "Neutropenia in a novel anti-mg-csf autoantibody mouse model" @default.
- W2079796654 doi "https://doi.org/10.1016/s0301-472x(00)00377-5" @default.
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