FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079796772> ?p ?o ?g. }

• W2079796772 endingPage "159" @default.
• W2079796772 startingPage "155" @default.
• W2079796772 abstract "Evidence showed that physical forces, as passive stretching or active contraction, may counteract various kinds of skeletal muscle atrophy due, for instance, to muscle immobilization, pathophysiology or denervation. Accordingly, active muscle contraction induced by functional electric stimulation is helpful to reduce the muscle atrophic state in denervated man. Moreover, there is evidence that also passive mechanical stimulation of the sarcolemnic membrane may reduce the atrophic muscle state. As to the mechanisms by which mechanical stimulation modulates muscle physiology and pathophysiology, there is a growing list of facts that signaling pathway to the nucleus involves stretch activated channels (SACs) of the sarcolemma and the cytoskeleton. SACs activation allowed a Ca(2+) inflow that activates Ca(2+)-dependent molecular signals. Cytoskeleton may be activated by Ca(2+)-dependent and -independent paths and its contraction and elongation represent not only a mechanical signal to the nucleus but also a stimulus for many molecular signals. The aim of this work was to evaluate in soleus muscle of the rat, the mechano-sensitivity of SACs before and after medium and long term denervation.Electrophysiologic experiments were made in normal and denervated Soleus muscle of Wistar rats. Currents were recorded in voltage clamp by intracellular microelectrodes inserted in a single fiber.Our findings demonstrated that SACs were expressed in normal soleus muscle and that SAC currents were potentiated by muscle stretching. Another important result was that the sensitivity to stretching increased after denervation and was particularly evident in long term denervated muscles.The reported effects are in agreement with the effects of exercise on inducing muscle hypertrophy or with the positive effects on repairing the atrophic state of skeletal muscles by mechanical stimulation or, in denervated humans, by the functional electrical stimulation (FES)." @default.
• W2079796772 created "2016-06-24" @default.
• W2079796772 creator A5014993729 @default.
• W2079796772 creator A5031456922 @default.
• W2079796772 creator A5052301689 @default.
• W2079796772 creator A5065405207 @default.
• W2079796772 creator A5090439916 @default.
• W2079796772 date "2008-03-01" @default.
• W2079796772 modified "2023-09-27" @default.
• W2079796772 title "Mechano-sensitivity of normal and long term denervated soleus muscle of the rat" @default.
• W2079796772 cites W1599277155 @default.
• W2079796772 cites W1646714051 @default.
• W2079796772 cites W1941910566 @default.
• W2079796772 cites W1977548231 @default.
• W2079796772 cites W2008714195 @default.
• W2079796772 cites W2014786409 @default.
• W2079796772 cites W2022533284 @default.
• W2079796772 cites W2035637866 @default.
• W2079796772 cites W2047641673 @default.
• W2079796772 cites W2048771411 @default.
• W2079796772 cites W2063916779 @default.
• W2079796772 cites W2108819917 @default.
• W2079796772 cites W2127808488 @default.
• W2079796772 cites W2128550761 @default.
• W2079796772 cites W2130747678 @default.
• W2079796772 cites W2130851152 @default.
• W2079796772 cites W2136563400 @default.
• W2079796772 cites W2147857868 @default.
• W2079796772 cites W2171290846 @default.
• W2079796772 cites W2366706442 @default.
• W2079796772 doi "https://doi.org/10.1179/174313208x281028" @default.
• W2079796772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18397607" @default.
• W2079796772 hasPublicationYear "2008" @default.
• W2079796772 type Work @default.
• W2079796772 sameAs 2079796772 @default.
• W2079796772 citedByCount "14" @default.
• W2079796772 countsByYear W20797967722013 @default.
• W2079796772 countsByYear W20797967722015 @default.
• W2079796772 countsByYear W20797967722020 @default.
• W2079796772 countsByYear W20797967722021 @default.
• W2079796772 countsByYear W20797967722022 @default.
• W2079796772 crossrefType "journal-article" @default.
• W2079796772 hasAuthorship W2079796772A5014993729 @default.
• W2079796772 hasAuthorship W2079796772A5031456922 @default.
• W2079796772 hasAuthorship W2079796772A5052301689 @default.
• W2079796772 hasAuthorship W2079796772A5065405207 @default.
• W2079796772 hasAuthorship W2079796772A5090439916 @default.
• W2079796772 hasConcept C105702510 @default.
• W2079796772 hasConcept C12554922 @default.
• W2079796772 hasConcept C126322002 @default.
• W2079796772 hasConcept C134018914 @default.
• W2079796772 hasConcept C163415756 @default.
• W2079796772 hasConcept C185592680 @default.
• W2079796772 hasConcept C199096232 @default.
• W2079796772 hasConcept C207200792 @default.
• W2079796772 hasConcept C24998067 @default.
• W2079796772 hasConcept C2776050358 @default.
• W2079796772 hasConcept C2776104385 @default.
• W2079796772 hasConcept C2776263037 @default.
• W2079796772 hasConcept C2776805190 @default.
• W2079796772 hasConcept C2779959927 @default.
• W2079796772 hasConcept C68731436 @default.
• W2079796772 hasConcept C71924100 @default.
• W2079796772 hasConcept C86803240 @default.
• W2079796772 hasConceptScore W2079796772C105702510 @default.
• W2079796772 hasConceptScore W2079796772C12554922 @default.
• W2079796772 hasConceptScore W2079796772C126322002 @default.
• W2079796772 hasConceptScore W2079796772C134018914 @default.
• W2079796772 hasConceptScore W2079796772C163415756 @default.
• W2079796772 hasConceptScore W2079796772C185592680 @default.
• W2079796772 hasConceptScore W2079796772C199096232 @default.
• W2079796772 hasConceptScore W2079796772C207200792 @default.
• W2079796772 hasConceptScore W2079796772C24998067 @default.
• W2079796772 hasConceptScore W2079796772C2776050358 @default.
• W2079796772 hasConceptScore W2079796772C2776104385 @default.
• W2079796772 hasConceptScore W2079796772C2776263037 @default.
• W2079796772 hasConceptScore W2079796772C2776805190 @default.
• W2079796772 hasConceptScore W2079796772C2779959927 @default.
• W2079796772 hasConceptScore W2079796772C68731436 @default.
• W2079796772 hasConceptScore W2079796772C71924100 @default.
• W2079796772 hasConceptScore W2079796772C86803240 @default.
• W2079796772 hasIssue "2" @default.
• W2079796772 hasLocation W20797967721 @default.
• W2079796772 hasLocation W20797967722 @default.
• W2079796772 hasOpenAccess W2079796772 @default.
• W2079796772 hasPrimaryLocation W20797967721 @default.
• W2079796772 hasRelatedWork W1657629837 @default.
• W2079796772 hasRelatedWork W1970395026 @default.
• W2079796772 hasRelatedWork W1977683234 @default.
• W2079796772 hasRelatedWork W2024549821 @default.
• W2079796772 hasRelatedWork W2050116915 @default.
• W2079796772 hasRelatedWork W2067600284 @default.
• W2079796772 hasRelatedWork W2079796772 @default.
• W2079796772 hasRelatedWork W2326180962 @default.
• W2079796772 hasRelatedWork W2365478954 @default.
• W2079796772 hasRelatedWork W4285403767 @default.
• W2079796772 hasVolume "30" @default.
• W2079796772 isParatext "false" @default.

• next