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- W2079799721 abstract "We have previously found that concanavalin A binds specifically to inositol and phosphatidylinositol. In the present study we demonstrate that binding of concanavalin A to liposomes containing phosphatidylinositol influences the uptake of such liposomes by macrophages. Although resident mouse peritoneal macrophages normally ingest liposomes only to a slight extent, attachment of concanavalin A to the liposomes caused a marked enhancement of phagocytosis. Furthermore induction of phagocytosis of concanavalin A-opsonized liposomes was associated with increased phosphatidylinositol turnover. We conclude that (a) concanavalin A can serve as an opsonizing agent for liposomes; (b) opsonization results from binding of concanavalin A to phosphatidylinositol on the liposomal surface; and (c) concanavalin A-induced phagocytosis is associated with increased phosphatidylinositol turnover in the macrophages." @default.
- W2079799721 created "2016-06-24" @default.
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- W2079799721 date "1986-08-01" @default.
- W2079799721 modified "2023-09-27" @default.
- W2079799721 title "Phosphatidylinositol liposomes opsonized by concanavalin a stimulate phosphatidylinositol turnover in macrophages" @default.
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- W2079799721 doi "https://doi.org/10.1016/s0006-291x(86)80394-1" @default.
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