Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079801896> ?p ?o ?g. }
- W2079801896 endingPage "131" @default.
- W2079801896 startingPage "95" @default.
- W2079801896 abstract "In the relatively short time since their introduction, beta-blockers have had an enormous impact on cardiovascular therapeutics and on many areas of clinical and physiological research. This has been quite unmatched by any other group of drugs. The stimulus for much of this work has arisen from continuing attempts to understand the mechanism by which beta-blockers lower blood pressure. Hemodynamic, renin-suppressive, central nervous system and a variety of other effects have been studied in detail but the explanation seems no closer than it was in the first few years of these investigations. On the other hand, this work has made important contributions to the understanding of cardiovascular physiology. The advent of beta-blockers has coincided with a time when views on the nature and treatment of hypertension have undergone considerable change. Hypertension is no longer regarded as a malignant and fulminating disease but rather as a prevalent, chronic and asymptomatic condition whose consequences are largely indistinguishable in type from the normal effects of cardiovascular ageing. This has led to a requirement for therapy in vast numbers of mildly hypertensive asymptomatic individuals, and has consequently shifted the therapeutic emphasis in the direction of patient acceptability. It is this, rather than any advantage in efficacy that has led to the ever-increasing use of beta-blockers now challenging even the place of thiazide diuretics as first choice drugs in essential hypertension. This trend is also apparent in the investigation and use of beta-blockers in certain hypertensive subgroups such as the pregnant and the elderly who in the past had been treated differently, if at all. Thus the advantages and drawbacks of beta-blocker therapy have become more clearly appreciated; at the same time, understanding of drug mechanism is advanced. Over a dozen different beta-blockers are now available. Some of these vary in relatively minor points of detail by the possession of beta1-adrenoceptor selectivity or partial agonist activity. In general these features have little influence either on therapeutic activity or on the incidence of adverse effects. In some cases, though, the severity of adverse reactions can be reduced, for example by using cardioselective agents in asthmatics and diabetics. In terms of efficacy and adverse effects, there is little to choose between beta-blockers and thiazide diuretics in the short term; equally, there are questions about the long term safety of both drugs still to be answered. However, the choice between these two agents must be influenced by the demonstration that beta-blockers have a modest though undoubted protective effect in patients who have suffered myocardial infarction. This is a major consideration and one which may yet have an important effect on therapeutic practice. It thus seems rational, in view of the predisposition of hypertensives to coronary artery disease, to use beta-blockers as first choice drugs in essential hypertension." @default.
- W2079801896 created "2016-06-24" @default.
- W2079801896 creator A5076675304 @default.
- W2079801896 creator A5079926491 @default.
- W2079801896 date "1983-01-01" @default.
- W2079801896 modified "2023-10-18" @default.
- W2079801896 title "Beta-adrenergic blocking drugs in the treatment of hypertension" @default.
- W2079801896 cites W1483141901 @default.
- W2079801896 cites W1484094566 @default.
- W2079801896 cites W1486599692 @default.
- W2079801896 cites W1493922046 @default.
- W2079801896 cites W1497912345 @default.
- W2079801896 cites W1504291244 @default.
- W2079801896 cites W1514939306 @default.
- W2079801896 cites W1528181437 @default.
- W2079801896 cites W1538860881 @default.
- W2079801896 cites W1547854467 @default.
- W2079801896 cites W1549915573 @default.
- W2079801896 cites W1556638135 @default.
- W2079801896 cites W1566804909 @default.
- W2079801896 cites W1567698748 @default.
- W2079801896 cites W1888607825 @default.
- W2079801896 cites W1897364932 @default.
- W2079801896 cites W1930820485 @default.
- W2079801896 cites W1935288670 @default.
- W2079801896 cites W1946286806 @default.
- W2079801896 cites W1946712122 @default.
- W2079801896 cites W1955076055 @default.
- W2079801896 cites W1968096377 @default.
- W2079801896 cites W1970045225 @default.
- W2079801896 cites W1970825199 @default.
- W2079801896 cites W1970877406 @default.
- W2079801896 cites W1971182462 @default.
- W2079801896 cites W1971183626 @default.
- W2079801896 cites W1971964485 @default.
- W2079801896 cites W1972024533 @default.
- W2079801896 cites W1972646254 @default.
- W2079801896 cites W1972668549 @default.
- W2079801896 cites W1972752435 @default.
- W2079801896 cites W1972780487 @default.
- W2079801896 cites W1974618465 @default.
- W2079801896 cites W1975123793 @default.
- W2079801896 cites W1977286235 @default.
- W2079801896 cites W1978111228 @default.
- W2079801896 cites W1979158838 @default.
- W2079801896 cites W1980496646 @default.
- W2079801896 cites W1980531737 @default.
- W2079801896 cites W1980778261 @default.
- W2079801896 cites W1980902536 @default.
- W2079801896 cites W1981048631 @default.
- W2079801896 cites W1981599777 @default.
- W2079801896 cites W1983990055 @default.
- W2079801896 cites W1984595407 @default.
- W2079801896 cites W1984678346 @default.
- W2079801896 cites W1984706820 @default.
- W2079801896 cites W1984875974 @default.
- W2079801896 cites W1990107374 @default.
- W2079801896 cites W1991605149 @default.
- W2079801896 cites W1991747071 @default.
- W2079801896 cites W1992426413 @default.
- W2079801896 cites W1992833088 @default.
- W2079801896 cites W1992997704 @default.
- W2079801896 cites W1995016032 @default.
- W2079801896 cites W1995445394 @default.
- W2079801896 cites W1995634036 @default.
- W2079801896 cites W1995806509 @default.
- W2079801896 cites W1996069322 @default.
- W2079801896 cites W1996291375 @default.
- W2079801896 cites W1996547078 @default.
- W2079801896 cites W1997388963 @default.
- W2079801896 cites W1997603985 @default.
- W2079801896 cites W1997655512 @default.
- W2079801896 cites W1999074818 @default.
- W2079801896 cites W1999754683 @default.
- W2079801896 cites W2001574622 @default.
- W2079801896 cites W2002530116 @default.
- W2079801896 cites W2003310006 @default.
- W2079801896 cites W2006929566 @default.
- W2079801896 cites W2007726218 @default.
- W2079801896 cites W2009980876 @default.
- W2079801896 cites W2010613526 @default.
- W2079801896 cites W2010827129 @default.
- W2079801896 cites W2011241344 @default.
- W2079801896 cites W2011253039 @default.
- W2079801896 cites W2012190155 @default.
- W2079801896 cites W2014564866 @default.
- W2079801896 cites W2014950781 @default.
- W2079801896 cites W2015490548 @default.
- W2079801896 cites W2015951862 @default.
- W2079801896 cites W2018551728 @default.
- W2079801896 cites W2019094489 @default.
- W2079801896 cites W2019591073 @default.
- W2079801896 cites W2020582261 @default.
- W2079801896 cites W2020872459 @default.
- W2079801896 cites W2020880171 @default.
- W2079801896 cites W2021609572 @default.
- W2079801896 cites W2021675281 @default.
- W2079801896 cites W2022219271 @default.