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- W2079803603 abstract "The role of lipid rafts in non-mammalian leukocytes has been scarcely investigated. We performed biochemical and functional analysis of lipid rafts in fish leukocytes. Fish Flotillin-1 and a fish GM1-like molecule (fGM1-L) were found in low density detergent-resistant membranes (LD-DRM) in goldfish macrophages and catfish B lymphocytes, similarly to mammals. The presence of flotillin-1 and fGM1-L in LD-DRM was sensitive to increased detergent concentrations, and cholesterol extraction. Confocal microscopy analysis of flotillin-1 and fGM1-L in fish leukocytes showed a distinctive punctuated staining pattern, suggestive of pre-existing rafts. Confocal microscopy analysis of macrophages showed that the membrane of phagosomes containing serum-opsonized zymosan was enriched in fGM1-L, and zymosan phagocytosis was reduced after cholesterol extraction. The presence of flotillin-1 and fGM1-L in LD-DRM, the microscopic evidence of flotillin-1 and fGM1-L on fish macrophages and B-cells, and the sensitivity of phagocytosis to cholesterol extraction, indicate that lipid rafts are biochemically and functionally similar in leukocytes from fish and mammals." @default.
- W2079803603 created "2016-06-24" @default.
- W2079803603 creator A5034406804 @default.
- W2079803603 creator A5042841355 @default.
- W2079803603 creator A5060958222 @default.
- W2079803603 creator A5072239752 @default.
- W2079803603 date "2012-06-01" @default.
- W2079803603 modified "2023-09-25" @default.
- W2079803603 title "Evidence for the presence of functional lipid rafts in immune cells of ectothermic organisms" @default.
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