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- W2079809161 abstract "Abstract: This study investigated the effect of p ‐methoxycinnamic acid ( p ‐MCA) on plasma glucose and insulin concentrations in normal and streptozotocin‐induced diabetic rats. In both fasting and glucose‐loading conditions, an oral administration of p ‐MCA (40–100 mg/kg) significantly decreased plasma glucose and also increased plasma insulin concentrations in both normal and diabetic rats. The onset of the p ‐MCA‐induced antihyperglycaemia/hypoglycaemia was observed at 1 hr after administration. In perfused rat pancreas, p ‐MCA (10–100 µM) stimulated insulin secretion about 1.4‐ and 3.1‐fold of basal–control group. In addition, p ‐MCA (10 µM) enhanced glucose‐induced insulin secretion. Moreover, p ‐MCA stimulated insulin secretion and increased intracellular Ca 2+ concentration ([Ca 2+ ] i ) in insulinoma‐1 cells. Taken together, our findings suggested that p ‐MCA exerted antihyperglycaemic/hypoglycaemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients." @default.
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- W2079809161 date "2008-03-16" @default.
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- W2079809161 title "Insulin-Secretagogue Activity of p-Methoxycinnamic Acid in Rats, Perfused Rat Pancreas and Pancreatic β-Cell Line" @default.
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- W2079809161 doi "https://doi.org/10.1111/j.1742-7843.2008.00218.x" @default.
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