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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079811425> ?p ?o ?g. }

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• W2079811425 abstract "The ability of the gp160 envelope glycoprotein of HIV-1 to activate human complement and to bind C3 fragments was investigated by incubating mammalian-derived recombinant gp160 with seronegative serum and by quantitating the binding of C3b/iC3b to the protein using a biotinylated monoclonal antibody directed against a neoepitope expressed by cleaved human C3. Recombinant gp160 activated complement in a dose- and time-dependent fashion. Complement activation occurred through the classical pathway, independently of antibodies, and required C1q. Binding of anti-HIV IgG to rgp160 prior to exposure of the envelope glycoprotein to serum resulted in enhanced complement activation. Complexes of rgp120 with anti-HIV IgG also cleaved C3 in serum, resulting in deposition of C3b on gp120. These results provide a basis for C3-mediated facilitation of viral entry into target cells expressing receptors for fragments of human C3." @default.
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• W2079811425 date "1993-03-01" @default.
• W2079811425 modified "2023-09-24" @default.
• W2079811425 title "Complement Activation by gp160 Glycoprotein of HIV-1" @default.
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• W2079811425 doi "https://doi.org/10.1089/aid.1993.9.229" @default.
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