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• W2079821314 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1999LONG-TERM SURVIVAL AFTER RADIOTHERAPY ALONE: RADIATION THERAPY ONCOLOGY GROUP PROSTATE CANCER TRIALS MACK ROACH, JIANDONG LU, MILJENKO V. PILEPICH, SUCHA O. ASBELL, MOHAMMED MOHIUDDIN, ROGER TERRY, and DAVID GRIGNON MACK ROACHMACK ROACH More articles by this author , JIANDONG LUJIANDONG LU More articles by this author , MILJENKO V. PILEPICHMILJENKO V. PILEPICH More articles by this author , SUCHA O. ASBELLSUCHA O. ASBELL More articles by this author , MOHAMMED MOHIUDDINMOHAMMED MOHIUDDIN More articles by this author , ROGER TERRYROGER TERRY More articles by this author , and DAVID GRIGNONDAVID GRIGNON More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61793-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We assess the relative importance of the several pretreatment characteristics in predicting death from prostate cancer in patients treated with curative intent with external beam radiotherapy alone. Materials and Methods: Patients entered on 4 prospective phase III randomized trials conducted by the Radiation Therapy Oncology Group between 1975 and 1992 were selected for this analysis if they were deemed evaluable and eligible for the trial, they had received no hormonal therapy with initial treatment and followup information was available. A disease specific survival event was declared if death was certified as due to prostate cancer, complications of treatment or unknown causes with clinically active malignancy. Median followup for patients treated on early and late studies exceeded 11 and 6 years, respectively. Results: Most of the patients (1,557) had tumors clinically staged at T3 (59%), and 87 (36%) with clinically staged T1-2 tumors had pathologically positive lymph nodes. On multivariate analysis Gleason score, clinical stage and nodal status were associated with a less favorable overall and disease specific survival, whereas others factors, such as age and race, were not. A Gleason score of 8 to 10 was associated with a high risk of dying of prostate cancer in the first 5 years (risk ratio 20.0, p = 0.0001). The 10-year disease specific survival for patients with a Gleason score of 2 to 5, 6 to 7 and 8 to 10 was 87, 75 and 44%, respectively, following radiotherapy. Based on published reports these rates were higher than expected with observation alone. Conclusions: In the first 10 years Gleason score was the single most important predictor of death. Gleason score should be incorporated into the current clinical staging system. References 1 : A decision analysis of alternative treatment strategies for clinically localized prostate cancer. J.A.M.A.1993; 269: 2650. Google Scholar 2 : Results of conservation management of clinically localized prostate cancer. New Engl. J. Med.1994; 330: 242. Google Scholar 3 : High 10-year survival rate in patients with early, untreated prostatic cancer. J.A.M.A.1992; 267: 2191. Google Scholar 4 : Long-term survival and mortality in prostate cancer treated with noncurative intent. J. Urol.1995; 154: 460. Link, Google Scholar 5 : Need for hospital care and palliative treatment for prostate cancer treated with noncurative intent. J. Urol.1995; 154: 466. 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Google Scholar From the Departments of Radiation Oncology, Medical Oncology and Urology, University of California, San Francisco and Department of Pathology, University of Southern California, Los Angeles, California, Radiation Therapy Oncology Group Statistical Headquarters and Department of Radiation Oncology, Einstein Medical Center, Philadelphia, Pennsylvania, Department of Pathology, Wayne State University, Detroit and Departments of Radiation Oncology, McAuley Health Center, Ann Arbor, Michigan, and University of Kentucky, Lexington, KentuckySupported by Radiation Therapy Oncology Group Grants U10 CA21661, CCOP U10, CA37422 and Stat U10 CA 32115 from the National Cancer Institute.(ROACH) Requests for reprints: Department of Radiation Oncology, University of California, San Francisco, 505 Parnassus Ave., San Francisco, California 94143-0226.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTewari A, Divine G, Chang P, Shemtov M, Milowsky M, Nanus D and Menon M (2018) Long-Term Survival in Men With High Grade Prostate Cancer: A Comparison Between Conservative Treatment, Radiation Therapy and Radical Prostatectomy—A Propensity Scoring ApproachJournal of Urology, VOL. 177, NO. 3, (911-915), Online publication date: 1-Mar-2007.ROSSER C, LEVY L, KUBAN D, CHICHAKLI R, POLLACK A, LEE A and PISTERS L (2018) Hazard Rates of Disease Progression After External Beam Radiotherapy for Clinically Localized Carcinoma of the ProstateJournal of Urology, VOL. 169, NO. 6, (2160-2165), Online publication date: 1-Jun-2003.Rosser C, Chichakli R, Levy L, Kuban D, Smith L and Pisters L (2018) Biochemical Disease-Free Survival in Men Younger Than 60 Years With Prostate Cancer Treated With External Beam RadiationJournal of Urology, VOL. 168, NO. 2, (536-541), Online publication date: 1-Aug-2002.GRAY C, POWELL C, RIFFENBURGH R and JOHNSTONE P (2018) 20-YEAR OUTCOME OF PATIENTS WITH T1–3N0 SURGICALLY STAGED PROSTATE CANCER TREATED WITH EXTERNAL BEAM RADIATION THERAPYJournal of Urology, VOL. 166, NO. 1, (116-118), Online publication date: 1-Jul-2001.FOWLER J, BIGLER S, BOWMAN G and KILAMBI N (2018) RACE AND CAUSE SPECIFIC SURVIVAL WITH PROSTATE CANCER: INFLUENCE OF CLINICAL STAGE, GLEASON SCORE, AGE AND TREATMENTJournal of Urology, VOL. 163, NO. 1, (137-142), Online publication date: 1-Jan-2000. Volume 161Issue 3March 1999Page: 864-868 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information MACK ROACH More articles by this author JIANDONG LU More articles by this author MILJENKO V. PILEPICH More articles by this author SUCHA O. ASBELL More articles by this author MOHAMMED MOHIUDDIN More articles by this author ROGER TERRY More articles by this author DAVID GRIGNON More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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