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• W2079832800 abstract "Although several guidelines do exist for freeze-drying process development and scale-up, there are still a number of issues that require additional attention. The objective of this review article is to discuss some emerging process development and scale-up issue with emphasis on effect of load condition and freeze-drying in novel container systems such as syringes, Lyoguard trays, ampoules, and 96-well plates. Understanding the heat and mass transfer under different load conditions and for freeze-drying in these novel container systems will help in developing a robust freeze-drying process which is also easier to scale-up. Further research and development needs in these emerging areas have also been addressed." @default.
• W2079832800 created "2016-06-24" @default.
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• W2079832800 date "2011-02-23" @default.
• W2079832800 modified "2023-10-04" @default.
• W2079832800 title "Emerging Freeze-Drying Process Development and Scale-up Issues" @default.
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• W2079832800 doi "https://doi.org/10.1208/s12249-011-9599-9" @default.
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