Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079839541> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2079839541 endingPage "e13" @default.
- W2079839541 startingPage "e10" @default.
- W2079839541 abstract "Objective To report the first postmarketing case of necrotizing pancreatitis in a patient on combination therapy of sitagliptin and exenatide. Methods We describe the patient’s clinical presentation, laboratory test results, imaging, and autopsy findings. Results A 76-year-old woman with a history of type 2 diabetes mellitus presented with severe abdominal pain, vomiting, and fever requiring hospital admission. She had been treated with exenatide for 3 years to manage her diabetes mellitus. A few weeks before presentation, sitagliptin was added, presumably to further optimize her glycemic control. Acute pancreatitis was diagnosed during hospital admission. At initial presentation, her serum amylase concentration was 1136 U/L (reference range, 10-130 U/L) and her lipase concentration was greater than 3500 U/L (reference range, 0-75 U/L). In addition, computed tomography of the abdomen and pelvis demonstrated extensive pancreatic parenchymal necrosis. She had undergone previous cholecystectomy, reported no alcohol consumption, and had a normal lipid profile. Although she had a long-standing history of diabetes mellitus, she had no history of pancreatitis or other risk factors that would have caused her to develop the underlying condition. After initial brief improvement, her symptoms worsened, and despite aggressive care, her clinical state deteriorated and she died. Autopsy findings demonstrated acute necrotizing pancreatitis with complete digestion of the pancreas. Conclusions Considering the temporal relationship of her symptoms to the addition of sitagliptin to her existing exenatide regimen, this case strongly suggests a possible causal link between exenatide or sitagliptin (or the combination of the 2 drugs) and the etiology of pancreatitis in this patient. (Endocr Pract. 2012;18:e10-e13)" @default.
- W2079839541 created "2016-06-24" @default.
- W2079839541 creator A5039494541 @default.
- W2079839541 creator A5047348046 @default.
- W2079839541 creator A5064245192 @default.
- W2079839541 creator A5078833112 @default.
- W2079839541 creator A5085226290 @default.
- W2079839541 date "2012-01-01" @default.
- W2079839541 modified "2023-10-07" @default.
- W2079839541 title "Case Report of Acute Necrotizing Pancreatitis Associated with Combination Treatment of Sitagliptin and Exenatide" @default.
- W2079839541 cites W1970638723 @default.
- W2079839541 cites W1984740259 @default.
- W2079839541 cites W2057913111 @default.
- W2079839541 cites W2075207587 @default.
- W2079839541 cites W2077397785 @default.
- W2079839541 cites W2092361523 @default.
- W2079839541 cites W2098008729 @default.
- W2079839541 cites W2140276611 @default.
- W2079839541 cites W2144149396 @default.
- W2079839541 cites W2164535707 @default.
- W2079839541 doi "https://doi.org/10.4158/ep11264.cr" @default.
- W2079839541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22068258" @default.
- W2079839541 hasPublicationYear "2012" @default.
- W2079839541 type Work @default.
- W2079839541 sameAs 2079839541 @default.
- W2079839541 citedByCount "38" @default.
- W2079839541 countsByYear W20798395412012 @default.
- W2079839541 countsByYear W20798395412013 @default.
- W2079839541 countsByYear W20798395412014 @default.
- W2079839541 countsByYear W20798395412015 @default.
- W2079839541 countsByYear W20798395412016 @default.
- W2079839541 countsByYear W20798395412017 @default.
- W2079839541 countsByYear W20798395412018 @default.
- W2079839541 countsByYear W20798395412019 @default.
- W2079839541 countsByYear W20798395412020 @default.
- W2079839541 countsByYear W20798395412022 @default.
- W2079839541 crossrefType "journal-article" @default.
- W2079839541 hasAuthorship W2079839541A5039494541 @default.
- W2079839541 hasAuthorship W2079839541A5047348046 @default.
- W2079839541 hasAuthorship W2079839541A5064245192 @default.
- W2079839541 hasAuthorship W2079839541A5078833112 @default.
- W2079839541 hasAuthorship W2079839541A5085226290 @default.
- W2079839541 hasConcept C126322002 @default.
- W2079839541 hasConcept C134018914 @default.
- W2079839541 hasConcept C141071460 @default.
- W2079839541 hasConcept C2775967933 @default.
- W2079839541 hasConcept C2776670229 @default.
- W2079839541 hasConcept C2777180221 @default.
- W2079839541 hasConcept C2779284873 @default.
- W2079839541 hasConcept C2780533449 @default.
- W2079839541 hasConcept C2780955771 @default.
- W2079839541 hasConcept C2910068830 @default.
- W2079839541 hasConcept C555293320 @default.
- W2079839541 hasConcept C71924100 @default.
- W2079839541 hasConcept C90924648 @default.
- W2079839541 hasConceptScore W2079839541C126322002 @default.
- W2079839541 hasConceptScore W2079839541C134018914 @default.
- W2079839541 hasConceptScore W2079839541C141071460 @default.
- W2079839541 hasConceptScore W2079839541C2775967933 @default.
- W2079839541 hasConceptScore W2079839541C2776670229 @default.
- W2079839541 hasConceptScore W2079839541C2777180221 @default.
- W2079839541 hasConceptScore W2079839541C2779284873 @default.
- W2079839541 hasConceptScore W2079839541C2780533449 @default.
- W2079839541 hasConceptScore W2079839541C2780955771 @default.
- W2079839541 hasConceptScore W2079839541C2910068830 @default.
- W2079839541 hasConceptScore W2079839541C555293320 @default.
- W2079839541 hasConceptScore W2079839541C71924100 @default.
- W2079839541 hasConceptScore W2079839541C90924648 @default.
- W2079839541 hasIssue "1" @default.
- W2079839541 hasLocation W20798395411 @default.
- W2079839541 hasOpenAccess W2079839541 @default.
- W2079839541 hasPrimaryLocation W20798395411 @default.
- W2079839541 hasRelatedWork W1970638723 @default.
- W2079839541 hasRelatedWork W1978831156 @default.
- W2079839541 hasRelatedWork W2080229805 @default.
- W2079839541 hasRelatedWork W2112981414 @default.
- W2079839541 hasRelatedWork W2124224832 @default.
- W2079839541 hasRelatedWork W2136039528 @default.
- W2079839541 hasRelatedWork W2159198773 @default.
- W2079839541 hasRelatedWork W2164535707 @default.
- W2079839541 hasRelatedWork W2187741930 @default.
- W2079839541 hasRelatedWork W4246918320 @default.
- W2079839541 hasVolume "18" @default.
- W2079839541 isParatext "false" @default.
- W2079839541 isRetracted "false" @default.
- W2079839541 magId "2079839541" @default.
- W2079839541 workType "article" @default.