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• W2079840143 abstract "Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study Junhui Su,1–3,* Cui Chang,3,* Qi Xiang,1,2 Zhi-Wei Zhou,4 Rong Luo,5 Lun Yang,6 Zhi-Xu He,7 Hongtu Yang,2,3 Jianan Li,1 Yu Bei,1 Jinmei Xu,1,2 Minjing Zhang,1 Qihao Zhang,1 Zhijian Su,1 Yadong Huang,1 Jiyan Pang,5 Shu-Feng Zhou4,7 1Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, 2Department of Pharmacy, Jinan University, Guangzhou, 3The People’s Hospital of Shenzhen City, Shenzhen, People’s Republic of China; 4Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 5School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 6Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 7Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, People’s Republic of China *These two authors contributed equally to this work Abstract: Natural compounds are becoming popular for the treatment of illnesses and health promotion, but the mechanisms of action and safety profiles are often unknown. Xyloketal B (XKB) is a novel marine compound isolated from the mangrove fungus Xylaria sp., with potent antioxidative, neuroprotective, and cardioprotective effects. However, its molecular targets and effects on drug-metabolizing enzymes are unknown. This study aimed to investigate the potential molecular targets of XKB using bioinformatic approaches and to examine the effect of XKB on the expression and activity of rat cytochrome P450 3a (Cyp3a) subfamily members using midazolam as a model probe. DDI-CPI, a server that can predict drug–drug interactions via the chemical–protein interactome, was employed to predict the targets of XKB, and the Database for Annotation, Visualization and Integrated Discovery (DAVID) was used to analyze the pathways of the predicted targets of XKB. Homology modeling was performed using the Discovery Studio program 3.1. The activity and expression of rat hepatic Cyp3a were examined after the rats were treated with XKB at 7 and 14 mg/kg for 8 consecutive days. Rat plasma concentrations of midazolam and its metabolite 1&#39;-OH-midazolam were determined using a validated high-performance liquid chromatographic method. Bioinformatic analysis showed that there were over 324 functional proteins and 61 related signaling pathways that were potentially regulated by XKB. A molecular docking study showed that XKB bound to the active site of human cytochrome P450 3A4 and rat Cyp3a2 homology model via the formation of hydrogen bonds. The in vivo study showed that oral administration of XKB at 14 mg/kg to rats for 8 days significantly increased the area under the plasma concentration-time curve (AUC) of midazolam, with a concomitant decrease in the plasma clearance and AUC ratio of 1&#39;-OH-midazolam over midazolam. Further, oral administration of 14 mg/kg XKB for 8 days markedly reduced the activity and expression of hepatic Cyp3a in rats. Taken together, the results show that XKB could regulate networks of molecular proteins and related signaling pathways and that XKB downregulated hepatic Cyp3a in rats. XKB might cause drug interactions through modulation of the activity and expression of Cyp3a members. More studies are warranted to confirm the mechanisms of action of XKB and to investigate the underlying mechanism for the regulating effect of XKB on Cyp3a subfamily members. Keywords: Xyloketal B, molecular target, cytochrome P450 3A, DDI-CPI tool, DAVID, midazolam, pharmacokinetics, rat, bioinformatics" @default.
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• W2079840143 date "2014-12-01" @default.
• W2079840143 modified "2023-10-16" @default.
• W2079840143 title "Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study" @default.
• W2079840143 cites W1547782763 @default.
• W2079840143 cites W1553908537 @default.
• W2079840143 cites W1868748626 @default.
• W2079840143 cites W1939820988 @default.
• W2079840143 cites W1966446944 @default.
• W2079840143 cites W1974907920 @default.
• W2079840143 cites W1976766480 @default.
• W2079840143 cites W1979495540 @default.
• W2079840143 cites W1979895110 @default.
• W2079840143 cites W1982728268 @default.
• W2079840143 cites W1984760370 @default.
• W2079840143 cites W1992716708 @default.
• W2079840143 cites W1994904603 @default.
• W2079840143 cites W1995544748 @default.
• W2079840143 cites W1997380101 @default.
• W2079840143 cites W1997408181 @default.
• W2079840143 cites W1999748605 @default.
• W2079840143 cites W2003984140 @default.
• W2079840143 cites W2008615531 @default.
• W2079840143 cites W2011967031 @default.
• W2079840143 cites W2013135431 @default.
• W2079840143 cites W2013475961 @default.
• W2079840143 cites W2017408113 @default.
• W2079840143 cites W2021350420 @default.
• W2079840143 cites W2026045959 @default.
• W2079840143 cites W2028403331 @default.
• W2079840143 cites W2038622868 @default.
• W2079840143 cites W2043249607 @default.
• W2079840143 cites W2057718195 @default.
• W2079840143 cites W2059006070 @default.
• W2079840143 cites W2061091339 @default.
• W2079840143 cites W2063909696 @default.
• W2079840143 cites W2077621515 @default.
• W2079840143 cites W2078927320 @default.
• W2079840143 cites W2082899043 @default.
• W2079840143 cites W2083869190 @default.
• W2079840143 cites W2089412983 @default.
• W2079840143 cites W2092285329 @default.
• W2079840143 cites W2111139603 @default.
• W2079840143 cites W2122402164 @default.
• W2079840143 cites W2130409285 @default.
• W2079840143 cites W2137775956 @default.
• W2079840143 cites W2142845387 @default.
• W2079840143 cites W2143251418 @default.
• W2079840143 cites W2146591007 @default.
• W2079840143 cites W2148370663 @default.
• W2079840143 cites W2151552217 @default.
• W2079840143 cites W2153000011 @default.
• W2079840143 cites W2156481297 @default.
• W2079840143 cites W2259925474 @default.
• W2079840143 cites W2313230176 @default.
• W2079840143 cites W2463310058 @default.
• W2079840143 cites W2085218842 @default.
• W2079840143 doi "https://doi.org/10.2147/dddt.s73476" @default.
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