Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079841451> ?p ?o ?g. }
- W2079841451 endingPage "785" @default.
- W2079841451 startingPage "769" @default.
- W2079841451 abstract "The clinical course in both polycythaemia vera (PV) and essential thrombocythaemia (ET) is characterized by significant thrombohaemorrhagic complications and variable risk of disease transformation into myeloid metaplasia with myelofibrosis or acute myeloid leukaemia. Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P. However, the use of chlorambucil or 32P has been associated with an increased risk of leukaemic transformation. Subsequently, other studies have suggested that both HU and pipobroman may be less leukaemogenic and as effective as chlorambucil and 32P for preventing thrombosis in PV. However, the results from these prospective studies have raised concern that even HU and pipobroman may be associated with excess leukaemic events in both ET and PV. The recent introduction of anagrelide as a specific platelet-lowering agent, the demonstration of treatment efficacy with interferon-alpha, and the revived interest in using low-dose acetylsalicylic acid provide the opportunity to initiate prospective randomized studies incorporating these treatments." @default.
- W2079841451 created "2016-06-24" @default.
- W2079841451 creator A5016216479 @default.
- W2079841451 creator A5061620364 @default.
- W2079841451 date "1998-12-01" @default.
- W2079841451 modified "2023-09-23" @default.
- W2079841451 title "4 Treatment of polycythaemia vera and essential thrombocythaemia" @default.
- W2079841451 cites W118940326 @default.
- W2079841451 cites W1421162947 @default.
- W2079841451 cites W1446966563 @default.
- W2079841451 cites W1481929343 @default.
- W2079841451 cites W1555518704 @default.
- W2079841451 cites W162907637 @default.
- W2079841451 cites W166660488 @default.
- W2079841451 cites W167119892 @default.
- W2079841451 cites W1760182239 @default.
- W2079841451 cites W1963876174 @default.
- W2079841451 cites W1964900372 @default.
- W2079841451 cites W1968887993 @default.
- W2079841451 cites W1969382756 @default.
- W2079841451 cites W1974615364 @default.
- W2079841451 cites W1978056379 @default.
- W2079841451 cites W1980029052 @default.
- W2079841451 cites W1986329429 @default.
- W2079841451 cites W1995607351 @default.
- W2079841451 cites W1996357128 @default.
- W2079841451 cites W1998325169 @default.
- W2079841451 cites W2001355703 @default.
- W2079841451 cites W2001758295 @default.
- W2079841451 cites W2003597939 @default.
- W2079841451 cites W2006092266 @default.
- W2079841451 cites W2007353459 @default.
- W2079841451 cites W2009104255 @default.
- W2079841451 cites W2009955884 @default.
- W2079841451 cites W2023286591 @default.
- W2079841451 cites W2028835250 @default.
- W2079841451 cites W2029353341 @default.
- W2079841451 cites W2039687934 @default.
- W2079841451 cites W2040917201 @default.
- W2079841451 cites W2041032609 @default.
- W2079841451 cites W2043834061 @default.
- W2079841451 cites W2044241739 @default.
- W2079841451 cites W2047449101 @default.
- W2079841451 cites W2052905336 @default.
- W2079841451 cites W2054940598 @default.
- W2079841451 cites W2056834859 @default.
- W2079841451 cites W2057383287 @default.
- W2079841451 cites W2059224997 @default.
- W2079841451 cites W2060968415 @default.
- W2079841451 cites W2061370440 @default.
- W2079841451 cites W2066723521 @default.
- W2079841451 cites W2068741393 @default.
- W2079841451 cites W2070635524 @default.
- W2079841451 cites W2072260269 @default.
- W2079841451 cites W2072691059 @default.
- W2079841451 cites W2075295588 @default.
- W2079841451 cites W2076145755 @default.
- W2079841451 cites W2076914763 @default.
- W2079841451 cites W2079873385 @default.
- W2079841451 cites W2082997796 @default.
- W2079841451 cites W2084549813 @default.
- W2079841451 cites W2087623186 @default.
- W2079841451 cites W2092298450 @default.
- W2079841451 cites W2099165047 @default.
- W2079841451 cites W2105827367 @default.
- W2079841451 cites W2117054170 @default.
- W2079841451 cites W2124551500 @default.
- W2079841451 cites W2134608013 @default.
- W2079841451 cites W2139560091 @default.
- W2079841451 cites W2142165201 @default.
- W2079841451 cites W2150938344 @default.
- W2079841451 cites W2157396497 @default.
- W2079841451 cites W2229971338 @default.
- W2079841451 cites W2240871144 @default.
- W2079841451 cites W2313541759 @default.
- W2079841451 cites W2317624320 @default.
- W2079841451 cites W2320032845 @default.
- W2079841451 cites W2329964205 @default.
- W2079841451 cites W2399669199 @default.
- W2079841451 cites W2411068800 @default.
- W2079841451 cites W2418413070 @default.
- W2079841451 cites W2462238653 @default.
- W2079841451 cites W266774159 @default.
- W2079841451 cites W2916719686 @default.
- W2079841451 cites W4214947912 @default.
- W2079841451 cites W45813627 @default.
- W2079841451 cites W46453237 @default.
- W2079841451 cites W9913207 @default.
- W2079841451 doi "https://doi.org/10.1016/s0950-3536(98)80038-3" @default.
- W2079841451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10640216" @default.
- W2079841451 hasPublicationYear "1998" @default.
- W2079841451 type Work @default.
- W2079841451 sameAs 2079841451 @default.
- W2079841451 citedByCount "17" @default.
- W2079841451 countsByYear W20798414512014 @default.
- W2079841451 countsByYear W20798414512016 @default.
- W2079841451 crossrefType "journal-article" @default.
- W2079841451 hasAuthorship W2079841451A5016216479 @default.