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- W2079841824 abstract "Malaria is a major global health problem that kills 1-2 million people each year. Despite exhaustive research, naturally acquired immunity is poorly understood. Cry1A proteins are potent immunogens with adjuvant properties and are able to induce strong cellular and humoral responses. In fact, it has been shown that administration of Cry1Ac protoxin alone or with amoebic lysates induces protection against the lethal infection caused by the protozoa Naegleria fowleri. In this work, we studied whether Cry1Ac is able to activate the innate immune response to induce protection against Plasmodium berghei ANKA (lethal) and P. chabaudi AS (nonlethal) parasites in CBA/Ca mice. Treatment with Cry1Ac induced protection against both Plasmodium species in terms of reduced parasitaemia, longer survival time, modulation of pro- and anti-inflammatory cytokines, and increased levels of specific antibodies against Plasmodium. Understanding how to boost innate immunity to Plasmodium infection should lead to immunologically based intervention strategies." @default.
- W2079841824 created "2016-06-24" @default.
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- W2079841824 date "2010-01-01" @default.
- W2079841824 modified "2023-10-01" @default.
- W2079841824 title "Pretreatment with Cry1Ac Protoxin Modulates the Immune Response, and Increases the Survival of<i>Plasmodium</i>-Infected CBA/Ca Mice" @default.
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- W2079841824 doi "https://doi.org/10.1155/2010/198921" @default.
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