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• W2079842057 abstract "Polyethylene glycol-polyethylenimine (PEG-PEI) nanogels have been used to deliver nucleic acids and oligonucleotides into cells. First, we synthesized PEG-PEI nanogels with methylene proton ratios (CH 2 O:CH 2 N) in PEG-PEI ranging from ∼6.8:1 to 4:1 and less, as shown by 1 H NMR spectra. We first synthesized various nanogels with varying ratios of CH 2 O:CH 2 N (methylene proton) in PEG-PEI as shown by 1 H NMR spectra and tested their cytotoxicity using a rodent pancreatic adenocarcinoma cell line (Pan 02). We showed that the nanogel PEG-PEI with methylene proton ratio of 4:1 was strongly cytotoxic to Pan 02 cells in vitro , while the nanogel with the methylene proton ratio of 6.8:1 was not toxic. We incorporated a novel anti-cancer drug, 6-(hydroxymethyl)-1,4-anthracenedione (AQ) analogue (AQ10) into nontoxic nanogel PEG-PEI and tested the effect of AQ10 loaded nanogel PEG-PEI (AQ10-nanogel PEG-PEI) and AQ10 dissolved in DMSO on Pan 02 cell growth. The size of this AQ10-nanogel PEG-PEI was characterized using atomic force microscopy (AFM). Our studies showed that the AQ10-nanogel PEG-PEI is readily taken up by Pan 02 cells. Growth attenuation of Pan 02 cells treated with AQ10-nanogel PEG-PEI was three to four times that of cells treated with AQ10 dissolved in DMSO. These results suggest that PEG-PEI, usually used to deliver nucleic acids into cells, can also be used to deliver an insoluble small molecule anticancer drug, AQ10." @default.
• W2079842057 created "2016-06-24" @default.
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• W2079842057 date "2008-05-01" @default.
• W2079842057 modified "2023-10-17" @default.
• W2079842057 title "Combination of Nanogel Polyethylene Glycol-Polyethylenimine and 6(hydroxymethyl)-1,4-anthracenedione as an Anticancer Nanomedicine" @default.
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• W2079842057 doi "https://doi.org/10.1166/jnn.2008.294" @default.
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