FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079843575> ?p ?o ?g. }

• W2079843575 endingPage "758" @default.
• W2079843575 startingPage "753" @default.
• W2079843575 abstract "Resistance of neoplastic cells to the alkylating drug BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] has been correlated with expression of O 6-methylguanine-DNA methyltransferase, which repairs the O 6-chloroethylguanine produced by the drug. Other possible mechanisms of resistance include raised levels of glutathione or increased repair of the DNA interstrand cross-links formed by BCNU. Transcriptional profiling revealed the upregulation of several metallothionein (MT) genes in a BCNU-resistant medulloblastoma cell line [D341 MED (OBR)] relative to its parental line. Previous studies have shown that MTs, through their reactive thiol groups can quench nitrogen mustard-derived alkylating drugs. In this report, we evaluate whether MTs can also quench BCNU. To demonstrate the binding of BCNU to MT, we used an assay that measured the release of the MT-bound divalent cations (Zn2+, Cd2+) upon their displacement by the drug. We also measured the decomposition rates of BCNU at those reaction conditions. The rate of release of the cations was higher in pH 7.4 than at pH 7.0, which is likely a result of more rapid decomposition of BCNU (thus faster release of MT-binding intermediate) at pH 7.4 than at pH 7.0. We demonstrate that resistance to BCNU may be a result of elevated levels of MTs which act by sequestering the drug’s decomposition product(s)." @default.
• W2079843575 created "2016-06-24" @default.
• W2079843575 creator A5004814459 @default.
• W2079843575 creator A5018176600 @default.
• W2079843575 creator A5021893284 @default.
• W2079843575 creator A5022953464 @default.
• W2079843575 creator A5057371623 @default.
• W2079843575 creator A5061678998 @default.
• W2079843575 creator A5064720738 @default.
• W2079843575 date "2008-07-17" @default.
• W2079843575 modified "2023-10-15" @default.
• W2079843575 title "BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line" @default.
• W2079843575 cites W1966288380 @default.
• W2079843575 cites W1967058623 @default.
• W2079843575 cites W1972562299 @default.
• W2079843575 cites W1977552409 @default.
• W2079843575 cites W1997045359 @default.
• W2079843575 cites W1998398302 @default.
• W2079843575 cites W2006747979 @default.
• W2079843575 cites W2016445028 @default.
• W2079843575 cites W2024559595 @default.
• W2079843575 cites W2044170441 @default.
• W2079843575 cites W2046854419 @default.
• W2079843575 cites W2062304932 @default.
• W2079843575 cites W2074848940 @default.
• W2079843575 cites W2078755014 @default.
• W2079843575 cites W2089978064 @default.
• W2079843575 cites W2095443177 @default.
• W2079843575 cites W2114905010 @default.
• W2079843575 cites W2129091720 @default.
• W2079843575 cites W2131196913 @default.
• W2079843575 cites W2147028372 @default.
• W2079843575 cites W2161314918 @default.
• W2079843575 cites W2214982708 @default.
• W2079843575 doi "https://doi.org/10.1007/s00280-008-0792-9" @default.
• W2079843575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3635115" @default.
• W2079843575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18633619" @default.
• W2079843575 hasPublicationYear "2008" @default.
• W2079843575 type Work @default.
• W2079843575 sameAs 2079843575 @default.
• W2079843575 citedByCount "12" @default.
• W2079843575 countsByYear W20798435752012 @default.
• W2079843575 countsByYear W20798435752013 @default.
• W2079843575 countsByYear W20798435752014 @default.
• W2079843575 countsByYear W20798435752015 @default.
• W2079843575 countsByYear W20798435752016 @default.
• W2079843575 countsByYear W20798435752021 @default.
• W2079843575 crossrefType "journal-article" @default.
• W2079843575 hasAuthorship W2079843575A5004814459 @default.
• W2079843575 hasAuthorship W2079843575A5018176600 @default.
• W2079843575 hasAuthorship W2079843575A5021893284 @default.
• W2079843575 hasAuthorship W2079843575A5022953464 @default.
• W2079843575 hasAuthorship W2079843575A5057371623 @default.
• W2079843575 hasAuthorship W2079843575A5061678998 @default.
• W2079843575 hasAuthorship W2079843575A5064720738 @default.
• W2079843575 hasBestOaLocation W20798435752 @default.
• W2079843575 hasConcept C104317684 @default.
• W2079843575 hasConcept C114851261 @default.
• W2079843575 hasConcept C127561419 @default.
• W2079843575 hasConcept C181199279 @default.
• W2079843575 hasConcept C185592680 @default.
• W2079843575 hasConcept C20719415 @default.
• W2079843575 hasConcept C2776694085 @default.
• W2079843575 hasConcept C2776946711 @default.
• W2079843575 hasConcept C2778119113 @default.
• W2079843575 hasConcept C2780147359 @default.
• W2079843575 hasConcept C2780789225 @default.
• W2079843575 hasConcept C502942594 @default.
• W2079843575 hasConcept C538909803 @default.
• W2079843575 hasConcept C54355233 @default.
• W2079843575 hasConcept C55493867 @default.
• W2079843575 hasConcept C81885089 @default.
• W2079843575 hasConcept C86803240 @default.
• W2079843575 hasConceptScore W2079843575C104317684 @default.
• W2079843575 hasConceptScore W2079843575C114851261 @default.
• W2079843575 hasConceptScore W2079843575C127561419 @default.
• W2079843575 hasConceptScore W2079843575C181199279 @default.
• W2079843575 hasConceptScore W2079843575C185592680 @default.
• W2079843575 hasConceptScore W2079843575C20719415 @default.
• W2079843575 hasConceptScore W2079843575C2776694085 @default.
• W2079843575 hasConceptScore W2079843575C2776946711 @default.
• W2079843575 hasConceptScore W2079843575C2778119113 @default.
• W2079843575 hasConceptScore W2079843575C2780147359 @default.
• W2079843575 hasConceptScore W2079843575C2780789225 @default.
• W2079843575 hasConceptScore W2079843575C502942594 @default.
• W2079843575 hasConceptScore W2079843575C538909803 @default.
• W2079843575 hasConceptScore W2079843575C54355233 @default.
• W2079843575 hasConceptScore W2079843575C55493867 @default.
• W2079843575 hasConceptScore W2079843575C81885089 @default.
• W2079843575 hasConceptScore W2079843575C86803240 @default.
• W2079843575 hasIssue "4" @default.
• W2079843575 hasLocation W20798435751 @default.
• W2079843575 hasLocation W20798435752 @default.
• W2079843575 hasLocation W20798435753 @default.
• W2079843575 hasLocation W20798435754 @default.
• W2079843575 hasOpenAccess W2079843575 @default.
• W2079843575 hasPrimaryLocation W20798435751 @default.
• W2079843575 hasRelatedWork W2050321855 @default.

• next