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• W2079844519 endingPage "643" @default.
• W2079844519 startingPage "636" @default.
• W2079844519 abstract "Elevation of extracellular potassium concentration ([K+]0) in cutaneous pectoris neuromuscular junction from 2 to 20 mM slowly increased the variability of the amplitudes of miniature end-plate currents (AMEPC-s), (coefficient of variation of AMEPC-s increased by 73%). Mean AMEPC-s, however, decreased but not markedly (by 14%). Comparable MEPC changes were observed when [K+] was raised in the presence of choline chloride (50 μM), arguing that MEPC changes were not primarily due to a lower and less uniform vesicular filling. Channel kinetics were not altered by high [K+]O, since the time constant of decay of miniature end-plate currents (TMEPC-s) did not change. Acetylcholine clearance from the synaptic cleft, however, appeared to be faster in high [K+ O since with cholinesterase blocked throughout, TMEPC-s were shortened. The changes of spontaneous quantal discharge induced by high [K+]0] can be almost entirely explained by altered spatial distribution of vesicular release if, as recent reports suggest, at high [K+],0, exocytosis appears randomly not only at but also in between the active zones. However, relatively greater frequency of large MEPCs suggests that in high [K+]0 some, and possibly all, quanta are filled above normal levels. High [Ca2+]0 appears to counteract, although not always completely, all changes in spontaneous quantal secretion induced by high [K+]0. It is possible that high [Ca2+]0 reverses the changes in the spatial distribution of vesicular release induced by high [K+]0. However, high [Ca2+]0 also leads to other pre- and postsynaptic changes." @default.
• W2079844519 created "2016-06-24" @default.
• W2079844519 creator A5044456642 @default.
• W2079844519 date "1988-01-01" @default.
• W2079844519 modified "2023-10-18" @default.
• W2079844519 title "Changes in miniature end-plate currents due to high potassium and calcium at the frog neuromuscular junction" @default.
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• W2079844519 doi "https://doi.org/10.1002/syn.890020610" @default.
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• W2079844519 hasPublicationYear "1988" @default.
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