Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079846914> ?p ?o ?g. }
- W2079846914 endingPage "148" @default.
- W2079846914 startingPage "140" @default.
- W2079846914 abstract "A d-glucose-free medium containing excess l-tyrosine was tested for its capacity to induce tyrosine aminotransferase in rat hepatoma cells (Reuber H-35). Approximately 2 × 107 cells, previously grown in Dulbecco modified Eagle medium were transferred to a similar medium which lacked d-glucose and contained excess l-tyrosine. Between 48 and 72 h later a sharp rise in tyrosine-aminotransferase activity occurred. Addition of d-glucose at 48 h completely suppressed this increase while l-glucose had no effect. Conversely, cultures incubated in media containing excess l-tyrosine in the presence of normal concentrations of d-glucose were not induced. After 48 h, however, changing from this medium to one which lacked d-glucose caused a sharp rise in tyrosine-aminotransferase activity within the next 24 h. The increase in enzyme activity in the absence of d-glucose was prevented by actinomycin-D and cycloheximide. It is unlikely that the absence of an energy-yielding substrate (d-glucose) caused enzyme induction since replacement of d-glucose with 2-deoxyglucose also suppressed tyrosine aminotransferase. Other compounds such as mannitol, lactose, and N-acetylglucosamine also suppressed synthesis of this enzyme. The data presented suggest that d-glucose suppresses synthesis by an action initiated at the cell surface." @default.
- W2079846914 created "2016-06-24" @default.
- W2079846914 creator A5025377123 @default.
- W2079846914 creator A5027285221 @default.
- W2079846914 creator A5075801763 @default.
- W2079846914 date "1971-12-01" @default.
- W2079846914 modified "2023-09-27" @default.
- W2079846914 title "d-Glucose Suppression of Tyrosine Aminotransferase in Rat-Hepatoma Cells Grown in Culture" @default.
- W2079846914 cites W1500057643 @default.
- W2079846914 cites W1501096338 @default.
- W2079846914 cites W1508920867 @default.
- W2079846914 cites W1523698595 @default.
- W2079846914 cites W1536070820 @default.
- W2079846914 cites W1538151656 @default.
- W2079846914 cites W1548772486 @default.
- W2079846914 cites W1571266414 @default.
- W2079846914 cites W1602459890 @default.
- W2079846914 cites W1604649689 @default.
- W2079846914 cites W1634560595 @default.
- W2079846914 cites W1775749144 @default.
- W2079846914 cites W178786212 @default.
- W2079846914 cites W188614741 @default.
- W2079846914 cites W1906197854 @default.
- W2079846914 cites W194138430 @default.
- W2079846914 cites W1941922732 @default.
- W2079846914 cites W1970177142 @default.
- W2079846914 cites W1975165283 @default.
- W2079846914 cites W1996606386 @default.
- W2079846914 cites W2001230396 @default.
- W2079846914 cites W2015213501 @default.
- W2079846914 cites W2024911718 @default.
- W2079846914 cites W2043805977 @default.
- W2079846914 cites W2052956575 @default.
- W2079846914 cites W206773894 @default.
- W2079846914 cites W2068366808 @default.
- W2079846914 cites W2070543423 @default.
- W2079846914 cites W2086719435 @default.
- W2079846914 cites W2088567352 @default.
- W2079846914 cites W2124709411 @default.
- W2079846914 cites W2130166091 @default.
- W2079846914 cites W2162050937 @default.
- W2079846914 cites W2413344347 @default.
- W2079846914 cites W3119646714 @default.
- W2079846914 cites W9299647 @default.
- W2079846914 cites W95220273 @default.
- W2079846914 doi "https://doi.org/10.1111/j.1432-1033.1971.tb19664.x" @default.
- W2079846914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4400338" @default.
- W2079846914 hasPublicationYear "1971" @default.
- W2079846914 type Work @default.
- W2079846914 sameAs 2079846914 @default.
- W2079846914 citedByCount "13" @default.
- W2079846914 crossrefType "journal-article" @default.
- W2079846914 hasAuthorship W2079846914A5025377123 @default.
- W2079846914 hasAuthorship W2079846914A5027285221 @default.
- W2079846914 hasAuthorship W2079846914A5075801763 @default.
- W2079846914 hasBestOaLocation W20798469141 @default.
- W2079846914 hasConcept C126322002 @default.
- W2079846914 hasConcept C132154277 @default.
- W2079846914 hasConcept C134018914 @default.
- W2079846914 hasConcept C181199279 @default.
- W2079846914 hasConcept C185592680 @default.
- W2079846914 hasConcept C2776165026 @default.
- W2079846914 hasConcept C2776491826 @default.
- W2079846914 hasConcept C2778128677 @default.
- W2079846914 hasConcept C2778445172 @default.
- W2079846914 hasConcept C3675279 @default.
- W2079846914 hasConcept C55493867 @default.
- W2079846914 hasConcept C71924100 @default.
- W2079846914 hasConcept C86803240 @default.
- W2079846914 hasConceptScore W2079846914C126322002 @default.
- W2079846914 hasConceptScore W2079846914C132154277 @default.
- W2079846914 hasConceptScore W2079846914C134018914 @default.
- W2079846914 hasConceptScore W2079846914C181199279 @default.
- W2079846914 hasConceptScore W2079846914C185592680 @default.
- W2079846914 hasConceptScore W2079846914C2776165026 @default.
- W2079846914 hasConceptScore W2079846914C2776491826 @default.
- W2079846914 hasConceptScore W2079846914C2778128677 @default.
- W2079846914 hasConceptScore W2079846914C2778445172 @default.
- W2079846914 hasConceptScore W2079846914C3675279 @default.
- W2079846914 hasConceptScore W2079846914C55493867 @default.
- W2079846914 hasConceptScore W2079846914C71924100 @default.
- W2079846914 hasConceptScore W2079846914C86803240 @default.
- W2079846914 hasIssue "1" @default.
- W2079846914 hasLocation W20798469141 @default.
- W2079846914 hasLocation W20798469142 @default.
- W2079846914 hasOpenAccess W2079846914 @default.
- W2079846914 hasPrimaryLocation W20798469141 @default.
- W2079846914 hasRelatedWork W1582513137 @default.
- W2079846914 hasRelatedWork W1615154137 @default.
- W2079846914 hasRelatedWork W2041773762 @default.
- W2079846914 hasRelatedWork W2066641096 @default.
- W2079846914 hasRelatedWork W2077452181 @default.
- W2079846914 hasRelatedWork W2079846914 @default.
- W2079846914 hasRelatedWork W2090405647 @default.
- W2079846914 hasRelatedWork W2091472909 @default.
- W2079846914 hasRelatedWork W2097683886 @default.
- W2079846914 hasRelatedWork W2109154705 @default.
- W2079846914 hasVolume "24" @default.