Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079852029> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2079852029 endingPage "593a" @default.
- W2079852029 startingPage "593a" @default.
- W2079852029 abstract "Introduction: Mitochondrial Ca2+ handling modulates the spatial and temporal profile of intracellular Ca2+ signaling. It is mainly mediated by the mitochondrial calcium uniporter (MCU). Uncoupling protein-2 (UCP2) a mitochondrial membrane protein has been proposed to be fundamental for MCU activity. Whether cellular excitation contraction (EC) coupling is modulated by UCP2 remains to be determined. Methods: To investigate this scenario, we isolated intact cardiomyocytes from adult wild-type (WT) and B6.129S4-Ucp2tm1Lowl/J (UCP2-/-) mice to analyze dual Ca2+ transients from the mitochondrial ((Ca2+)m) and intracellular compartment ((Ca2+)c) in the whole cell configuration using Rhod2-AM and Fluo4 pentapotassium salt. We also tested whether the previously described inhibitory effect of ATP on mitochondrial Ca2+ uptake could be mediated by UCP2. To detect possible regulatory effects on sarcolemmal Ca2+ uptake in UCP2-/- mice, trigger Ca2+ influx was measured using Ryanodine. Results: In cardiomyocytes of WT mice (Ca2+)m was selectively decreased by Ruthenium360 (Ru360) while (Ca2+)c was upregulated. The (Ca2+)m was decreased in UCP2-/- myocytes compared to WT while (Ca2+)c was unchanged suggesting a compensational modulation of EC coupling. Trigger Ca2+ influx was reduced in UCP2-/- vs. WT myocytes, presumably to prevent cytosolic Ca2+ overload. Additionally, we observed an inhibitory effect of ATP on mitochondrial Ca2+ uptake in myocytes of WT mice while no effect was observed in UCP2-/- mice. Conclusion: Our experiments suggest a possible role of MCU and UCP2 interaction in controlling mitochondrial Ca2+ uptake as well as EC coupling." @default.
- W2079852029 created "2016-06-24" @default.
- W2079852029 creator A5000726341 @default.
- W2079852029 creator A5009922598 @default.
- W2079852029 creator A5015571067 @default.
- W2079852029 creator A5024498880 @default.
- W2079852029 creator A5034674366 @default.
- W2079852029 creator A5040800792 @default.
- W2079852029 creator A5056689756 @default.
- W2079852029 creator A5070452281 @default.
- W2079852029 date "2014-01-01" @default.
- W2079852029 modified "2023-09-28" @default.
- W2079852029 title "Ucp2 Modulates Cellular Excitation Contraction Coupling via Mitochondrial Calcium Uptake" @default.
- W2079852029 doi "https://doi.org/10.1016/j.bpj.2013.11.3283" @default.
- W2079852029 hasPublicationYear "2014" @default.
- W2079852029 type Work @default.
- W2079852029 sameAs 2079852029 @default.
- W2079852029 citedByCount "1" @default.
- W2079852029 countsByYear W20798520292015 @default.
- W2079852029 crossrefType "journal-article" @default.
- W2079852029 hasAuthorship W2079852029A5000726341 @default.
- W2079852029 hasAuthorship W2079852029A5009922598 @default.
- W2079852029 hasAuthorship W2079852029A5015571067 @default.
- W2079852029 hasAuthorship W2079852029A5024498880 @default.
- W2079852029 hasAuthorship W2079852029A5034674366 @default.
- W2079852029 hasAuthorship W2079852029A5040800792 @default.
- W2079852029 hasAuthorship W2079852029A5056689756 @default.
- W2079852029 hasAuthorship W2079852029A5070452281 @default.
- W2079852029 hasBestOaLocation W20798520291 @default.
- W2079852029 hasConcept C113217602 @default.
- W2079852029 hasConcept C12554922 @default.
- W2079852029 hasConcept C131584629 @default.
- W2079852029 hasConcept C134018914 @default.
- W2079852029 hasConcept C163415756 @default.
- W2079852029 hasConcept C178790620 @default.
- W2079852029 hasConcept C181199279 @default.
- W2079852029 hasConcept C181911157 @default.
- W2079852029 hasConcept C185592680 @default.
- W2079852029 hasConcept C191897082 @default.
- W2079852029 hasConcept C192562407 @default.
- W2079852029 hasConcept C201571599 @default.
- W2079852029 hasConcept C207200792 @default.
- W2079852029 hasConcept C28859421 @default.
- W2079852029 hasConcept C35341161 @default.
- W2079852029 hasConcept C519063684 @default.
- W2079852029 hasConcept C55493867 @default.
- W2079852029 hasConcept C62478195 @default.
- W2079852029 hasConcept C66135807 @default.
- W2079852029 hasConcept C79879829 @default.
- W2079852029 hasConcept C80631254 @default.
- W2079852029 hasConcept C86803240 @default.
- W2079852029 hasConcept C95444343 @default.
- W2079852029 hasConcept C98539663 @default.
- W2079852029 hasConceptScore W2079852029C113217602 @default.
- W2079852029 hasConceptScore W2079852029C12554922 @default.
- W2079852029 hasConceptScore W2079852029C131584629 @default.
- W2079852029 hasConceptScore W2079852029C134018914 @default.
- W2079852029 hasConceptScore W2079852029C163415756 @default.
- W2079852029 hasConceptScore W2079852029C178790620 @default.
- W2079852029 hasConceptScore W2079852029C181199279 @default.
- W2079852029 hasConceptScore W2079852029C181911157 @default.
- W2079852029 hasConceptScore W2079852029C185592680 @default.
- W2079852029 hasConceptScore W2079852029C191897082 @default.
- W2079852029 hasConceptScore W2079852029C192562407 @default.
- W2079852029 hasConceptScore W2079852029C201571599 @default.
- W2079852029 hasConceptScore W2079852029C207200792 @default.
- W2079852029 hasConceptScore W2079852029C28859421 @default.
- W2079852029 hasConceptScore W2079852029C35341161 @default.
- W2079852029 hasConceptScore W2079852029C519063684 @default.
- W2079852029 hasConceptScore W2079852029C55493867 @default.
- W2079852029 hasConceptScore W2079852029C62478195 @default.
- W2079852029 hasConceptScore W2079852029C66135807 @default.
- W2079852029 hasConceptScore W2079852029C79879829 @default.
- W2079852029 hasConceptScore W2079852029C80631254 @default.
- W2079852029 hasConceptScore W2079852029C86803240 @default.
- W2079852029 hasConceptScore W2079852029C95444343 @default.
- W2079852029 hasConceptScore W2079852029C98539663 @default.
- W2079852029 hasIssue "2" @default.
- W2079852029 hasLocation W20798520291 @default.
- W2079852029 hasOpenAccess W2079852029 @default.
- W2079852029 hasPrimaryLocation W20798520291 @default.
- W2079852029 hasRelatedWork W1479927002 @default.
- W2079852029 hasRelatedWork W1518598287 @default.
- W2079852029 hasRelatedWork W1970887126 @default.
- W2079852029 hasRelatedWork W2042522166 @default.
- W2079852029 hasRelatedWork W2059796874 @default.
- W2079852029 hasRelatedWork W2071225392 @default.
- W2079852029 hasRelatedWork W2079852029 @default.
- W2079852029 hasRelatedWork W2121808182 @default.
- W2079852029 hasRelatedWork W2210851404 @default.
- W2079852029 hasRelatedWork W2414522080 @default.
- W2079852029 hasVolume "106" @default.
- W2079852029 isParatext "false" @default.
- W2079852029 isRetracted "false" @default.
- W2079852029 magId "2079852029" @default.
- W2079852029 workType "article" @default.