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- W2079859248 abstract "As the whole genome sequences of increasing numbers of organisms are becoming available, novel approaches are needed to convert these data into functional information. Microarrays of immobilized DNA or oligonucleotides (so-called DNA chips) are providing a powerful tool to monitor the simultaneous expression of thousands of genes. This has been recently demonstrated in two studies addressing the responses of Saccharomyces cerevisiae to the metabolic shift from fermentation to respiration, to mutations affecting transcriptional activators and to growth in rich vs. minimal medium. While DeRisi et al., 1997xExploring the metabolic and genetic control of gene expression on a genomic scale. DeRisi, J.L., Iyer, V.R., and Brown, P.O. Science. 1997; 278: 680–686Crossref | PubMed | Scopus (3267)See all ReferencesDeRisi et al., 1997have probed DNA microarrays containing ∼6400 distinct DNA sequences, corresponding to most yeast genes, Wodicka et al., 1997xGenome-wide expression monitoring in Saccharomyces cerevisiae. Wodicka, L. et al. Nat. Biotechnol. 1997; 15: 1359–1367Crossref | PubMed | Scopus (806)See all ReferencesWodicka et al., 1997have used a set of four arrays containing a total of 260 000 oligonucleotides, which can be used to detect the expression of all S. cerevisiae genes at levels as low as 0.1 copy per cell. Both studies have uncovered changes in the expression of many previously uncharacterized genes, thus providing clues to their function. The recent report by de Saizieu et al., 1997xBacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays. de Saizieu, A. et al. Nat. Biotechnol. 1997; 16: 45–48Crossref | Scopus (188)See all Referencesde Saizieu et al., 1997shows that this strategy is also suitable for the study of gene expression in bacteria using total RNA instead of purified mRNA as a probe. Thus, the use of DNA chips to monitor gene expression at a genomic scale will soon become accessible for many microorganisms and will greatly contribute to our understanding of microorganism–host/environment relationships." @default.
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- W2079859248 date "1998-04-01" @default.
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- W2079859248 title "Chipping away at genomes" @default.
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- W2079859248 doi "https://doi.org/10.1016/s0966-842x(98)01253-0" @default.
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