FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079861630> ?p ?o ?g. }

• W2079861630 endingPage "6404" @default.
• W2079861630 startingPage "6396" @default.
• W2079861630 abstract "Abstract We have found previously that acquired doxorubicin resistance in a genetically engineered mouse model for BRCA1-related breast cancer was associated with increased expression of the mouse multidrug resistance (Mdr1) genes, which encode the drug efflux transporter ATP-binding cassette B1/P-glycoprotein (P-gp). Here, we show that even moderate increases of Mdr1 expression (as low as 5-fold) are sufficient to cause doxorubicin resistance. These moderately elevated tumor P-gp levels are below those found in some normal tissues, such as the gut. The resistant phenotype could be completely reversed by the third-generation P-gp inhibitor tariquidar, which provides a useful strategy to circumvent this type of acquired doxorubicin resistance. The presence of MDR1A in drug-resistant tumors with a moderate increase in Mdr1a transcripts could be shown with a newly generated chicken antibody against a mouse P-gp peptide. Our data show the usefulness of realistic preclinical models to characterize levels of Mdr1 gene expression that are sufficient to cause resistance. [Cancer Res 2009;69(16):6396–9]" @default.
• W2079861630 created "2016-06-24" @default.
• W2079861630 creator A5017173720 @default.
• W2079861630 creator A5049270608 @default.
• W2079861630 creator A5055147140 @default.
• W2079861630 creator A5060054431 @default.
• W2079861630 creator A5061340130 @default.
• W2079861630 creator A5066160219 @default.
• W2079861630 creator A5069143905 @default.
• W2079861630 creator A5073106472 @default.
• W2079861630 date "2009-08-12" @default.
• W2079861630 modified "2023-09-27" @default.
• W2079861630 title "Moderate Increase in <i>Mdr1a/1b</i> Expression Causes <i>In vivo</i> Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer" @default.
• W2079861630 cites W1485874288 @default.
• W2079861630 cites W1522603082 @default.
• W2079861630 cites W1595815978 @default.
• W2079861630 cites W1724512254 @default.
• W2079861630 cites W1828694471 @default.
• W2079861630 cites W1837265740 @default.
• W2079861630 cites W1963842583 @default.
• W2079861630 cites W1980319850 @default.
• W2079861630 cites W1982542571 @default.
• W2079861630 cites W1986222466 @default.
• W2079861630 cites W1992496728 @default.
• W2079861630 cites W1992661182 @default.
• W2079861630 cites W2007931369 @default.
• W2079861630 cites W2008449321 @default.
• W2079861630 cites W2012076841 @default.
• W2079861630 cites W2014599726 @default.
• W2079861630 cites W2016599680 @default.
• W2079861630 cites W2018652769 @default.
• W2079861630 cites W2021785773 @default.
• W2079861630 cites W2041594739 @default.
• W2079861630 cites W2044774111 @default.
• W2079861630 cites W2046112186 @default.
• W2079861630 cites W2049572301 @default.
• W2079861630 cites W2051808614 @default.
• W2079861630 cites W2055904567 @default.
• W2079861630 cites W2056447531 @default.
• W2079861630 cites W2062756319 @default.
• W2079861630 cites W2073198041 @default.
• W2079861630 cites W2075130560 @default.
• W2079861630 cites W2082288172 @default.
• W2079861630 cites W2083314681 @default.
• W2079861630 cites W2103394810 @default.
• W2079861630 cites W2115439933 @default.
• W2079861630 cites W2125850107 @default.
• W2079861630 cites W2126097291 @default.
• W2079861630 cites W2127229019 @default.
• W2079861630 cites W2133408654 @default.
• W2079861630 cites W2136564762 @default.
• W2079861630 cites W2145450437 @default.
• W2079861630 cites W2152546397 @default.
• W2079861630 cites W2163205674 @default.
• W2079861630 cites W2166153381 @default.
• W2079861630 cites W2166825080 @default.
• W2079861630 cites W2271456353 @default.
• W2079861630 cites W4253474173 @default.
• W2079861630 doi "https://doi.org/10.1158/0008-5472.can-09-0041" @default.
• W2079861630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19654309" @default.
• W2079861630 hasPublicationYear "2009" @default.
• W2079861630 type Work @default.
• W2079861630 sameAs 2079861630 @default.
• W2079861630 citedByCount "82" @default.
• W2079861630 countsByYear W20798616302012 @default.
• W2079861630 countsByYear W20798616302013 @default.
• W2079861630 countsByYear W20798616302014 @default.
• W2079861630 countsByYear W20798616302015 @default.
• W2079861630 countsByYear W20798616302016 @default.
• W2079861630 countsByYear W20798616302017 @default.
• W2079861630 countsByYear W20798616302018 @default.
• W2079861630 countsByYear W20798616302019 @default.
• W2079861630 countsByYear W20798616302020 @default.
• W2079861630 countsByYear W20798616302021 @default.
• W2079861630 countsByYear W20798616302022 @default.
• W2079861630 countsByYear W20798616302023 @default.
• W2079861630 crossrefType "journal-article" @default.
• W2079861630 hasAuthorship W2079861630A5017173720 @default.
• W2079861630 hasAuthorship W2079861630A5049270608 @default.
• W2079861630 hasAuthorship W2079861630A5055147140 @default.
• W2079861630 hasAuthorship W2079861630A5060054431 @default.
• W2079861630 hasAuthorship W2079861630A5061340130 @default.
• W2079861630 hasAuthorship W2079861630A5066160219 @default.
• W2079861630 hasAuthorship W2079861630A5069143905 @default.
• W2079861630 hasAuthorship W2079861630A5073106472 @default.
• W2079861630 hasBestOaLocation W20798616302 @default.
• W2079861630 hasConcept C104317684 @default.
• W2079861630 hasConcept C114851261 @default.
• W2079861630 hasConcept C121608353 @default.
• W2079861630 hasConcept C133936738 @default.
• W2079861630 hasConcept C149011108 @default.
• W2079861630 hasConcept C150194340 @default.
• W2079861630 hasConcept C200082930 @default.
• W2079861630 hasConcept C207001950 @default.
• W2079861630 hasConcept C2776694085 @default.
• W2079861630 hasConcept C2778707650 @default.
• W2079861630 hasConcept C2781303535 @default.
• W2079861630 hasConcept C44312359 @default.

• next