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- W2079862395 abstract "Purpose of review Current antiretroviral therapies have dramatically changed the disease course of HIV infection. Although antiretroviral therapy is effective at decreasing viral replication and preserving CD4+ T-cell numbers, low-level immune activation and inflammation persist in virally suppressed HIV-infected patients. This chronic immune activation/inflammation may contribute to an increased risk for venous and arterial thrombosis. Recent findings Several markers of coagulation and inflammation are increased in HIV-infected patients. The Strategies for the Management of Antiretroviral Therapy study reported that plasma D-dimer levels, a marker of fibrinolysis, independently predicted morbidity in HIV-infected patients. Increased plasma and cell surface levels of the procoagulant tissue factor have also been reported in patients with HIV disease. Fibrinogen, von Willebrand factor, and P-selectin are likewise increased in plasma samples of HIV-infected patients; all of these markers suggest HIV-infection results in a procoagulant state. Treatment with antiretroviral therapy reduces, but does not always normalize, levels of biomarkers associated with inflammation and coagulation in HIV+ patients. Summary HIV-infected patients are at greater risk for both venous and arterial thrombosis. Chronic immune activation and inflammation in these patients appears to contribute to coagulation risk. Antiretroviral therapy reduces viral replication, immune activation, and markers of coagulation, but these indices do not always return to normal, even after several years of viremic control." @default.
- W2079862395 created "2016-06-24" @default.
- W2079862395 creator A5023967411 @default.
- W2079862395 date "2014-01-01" @default.
- W2079862395 modified "2023-10-01" @default.
- W2079862395 title "Markers of coagulation and inflammation often remain elevated in ART-treated HIV-infected patients" @default.
- W2079862395 cites W1426208733 @default.
- W2079862395 cites W1497170016 @default.
- W2079862395 cites W1552156688 @default.
- W2079862395 cites W1588051837 @default.
- W2079862395 cites W1767400858 @default.
- W2079862395 cites W1811402656 @default.
- W2079862395 cites W1971456874 @default.
- W2079862395 cites W1975953426 @default.
- W2079862395 cites W1978891884 @default.
- W2079862395 cites W1979252165 @default.
- W2079862395 cites W1980425507 @default.
- W2079862395 cites W1981126412 @default.
- W2079862395 cites W1987478554 @default.
- W2079862395 cites W1988435860 @default.
- W2079862395 cites W1989576769 @default.
- W2079862395 cites W1996459980 @default.
- W2079862395 cites W1999601106 @default.
- W2079862395 cites W2006417252 @default.
- W2079862395 cites W2008917776 @default.
- W2079862395 cites W2012768600 @default.
- W2079862395 cites W2021097026 @default.
- W2079862395 cites W2024050058 @default.
- W2079862395 cites W2024287736 @default.
- W2079862395 cites W2026053420 @default.
- W2079862395 cites W2028657303 @default.
- W2079862395 cites W2029148240 @default.
- W2079862395 cites W2029539300 @default.
- W2079862395 cites W2029884260 @default.
- W2079862395 cites W2039816125 @default.
- W2079862395 cites W2041008947 @default.
- W2079862395 cites W2046166857 @default.
- W2079862395 cites W2046851673 @default.
- W2079862395 cites W2047325790 @default.
- W2079862395 cites W2047513859 @default.
- W2079862395 cites W2049221965 @default.
- W2079862395 cites W2049539466 @default.
- W2079862395 cites W2050125360 @default.
- W2079862395 cites W2052644327 @default.
- W2079862395 cites W2055156716 @default.
- W2079862395 cites W2059619325 @default.
- W2079862395 cites W2062430786 @default.
- W2079862395 cites W2063170999 @default.
- W2079862395 cites W2063639831 @default.
- W2079862395 cites W2064835422 @default.
- W2079862395 cites W2067230484 @default.
- W2079862395 cites W2069148320 @default.
- W2079862395 cites W2070457788 @default.
- W2079862395 cites W2072339607 @default.
- W2079862395 cites W2074559523 @default.
- W2079862395 cites W2076675316 @default.
- W2079862395 cites W2078529164 @default.
- W2079862395 cites W2086893453 @default.
- W2079862395 cites W2092029818 @default.
- W2079862395 cites W2094458559 @default.
- W2079862395 cites W2095919911 @default.
- W2079862395 cites W2098152094 @default.
- W2079862395 cites W2101889073 @default.
- W2079862395 cites W2102223205 @default.
- W2079862395 cites W2105290874 @default.
- W2079862395 cites W2110559078 @default.
- W2079862395 cites W2110846660 @default.
- W2079862395 cites W2113369935 @default.
- W2079862395 cites W2114519789 @default.
- W2079862395 cites W2118247493 @default.
- W2079862395 cites W2121850733 @default.
- W2079862395 cites W2122483069 @default.
- W2079862395 cites W2123354892 @default.
- W2079862395 cites W2124551895 @default.
- W2079862395 cites W2127517680 @default.
- W2079862395 cites W2130603879 @default.
- W2079862395 cites W2135687987 @default.
- W2079862395 cites W2141813332 @default.
- W2079862395 cites W2148314152 @default.
- W2079862395 cites W2153136696 @default.
- W2079862395 cites W2159360702 @default.
- W2079862395 cites W2167709851 @default.
- W2079862395 cites W2169083127 @default.
- W2079862395 cites W2171523916 @default.
- W2079862395 cites W2172341846 @default.
- W2079862395 cites W2318289184 @default.
- W2079862395 cites W4296391115 @default.
- W2079862395 cites W46341902 @default.
- W2079862395 doi "https://doi.org/10.1097/coh.0000000000000019" @default.
- W2079862395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3982388" @default.
- W2079862395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24275673" @default.
- W2079862395 hasPublicationYear "2014" @default.
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